Earticle

초록

영어

Prenatal stress causes learning deficits by inhibiting neurogenesis in the hippocampus. We studied the effects of maternal treadmill running or offspring treadmill running on the spatial learning ability of adoles-cent offspring rats or adult offspring rats born to maternal rats that re-ceived stress during pregnancy. For this study, spatial learning ability was measured by radial 8-arm maze task. Immunohistochemistry for 5-bromo-2’-deoxyuridine and Western blot for brain-derived neuro-trophic factor (BDNF), tyrosine kinase B (TrkB), Bcl-2-associated X pro-tein (Bax), and B-cell lymphoma 2 (Bcl-2) were also conducted. Stress was induced by exposing pregnant rats to hound in an enclosed room. Maternal treadmill running or treadmill running of offspring improved spatial learning ability of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or treadmill running of offspring increased hippocampal cell proliferation of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or tread-mill running of offspring increased BDNF and TrkB expression in the hippocampus of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or treadmill running of offspring inhibited Bax expression and increased Bcl-2 expression in the hippocampus of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Mother’s exercise during pregnancy or child’s exercise after childbirth can im-prove the spatial learning ability deteriorated due to stress during preg-nancy.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Adolescent and adult rats
Inducing stress in pregnant rats
Exercise protocol
Radial 8-arm maze task
Tissue preparation
Immunohistochemistry for BrdU
Western blot for BDNF, TrkB, Bax, and Bcl-2
Data analysis
RESULTS
Spatial learning ability
Cell proliferation
BDNF and TrkB expression
Bax and Bcl-2 expression
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Tae-Woon Kim [ Department of Human Health Care, Gyeongsang National University, Jinju, Korea ]
• Young Jun Ko [ Major in Sport Service Practice, College of Welfare Convergence, Kangnam University, Yongin, Korea ]
• Ki-Hyok Youn [ Department of Social Welfare, College of Health, Welfare and Education, Tongmyong University, Busan, Korea ]
• Boo-Geun Hwang [ Department of Sport Rehabilitation, College of Health, Welfare and Education, Tongmyong University, Busan, Korea ]
• Hyun-Seok Bang [ Department of Sport Rehabilitation, College of Health, Welfare and Education, Tongmyong University, Busan, Korea ]
• Sam-Jun Lee [ Department of Sport Rehabilitation, College of Health, Welfare and Education, Tongmyong University, Busan, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613