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Review Article

Effect of physical exercise on cognitive function in older adults’ carriers versus noncarriers of apolipoprotein E4 : systematic review and meta-analysis

첫 페이지 보기
  • 발행기관
    한국운동재활학회 바로가기
  • 간행물
    JER SCOPUS KCI 등재 바로가기
  • 통권
    Vol.17 No.2 (2021.04)바로가기
  • 페이지
    pp.69-80
  • 저자
    José María Cancela-Carral, Adriana López-Rodríguez, Irimia Mollinedo-Cardalda
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A393621

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원문정보

초록

영어
The presence of apolipoprotein (Apo) E4 is a genetic risk factor in cog-nitive impairment. Physical exercise contributes to slowing cognitive impairment in older adults, but little is known about the influence of ex-ercise on ApoE4 carriers and noncarriers. The objective of systematic review is to study the role of physical exercise in older adults’ ApoE4 carriers and noncarriers. A systematic literature search was carried out in five international databases: PubMed, Web of Science, PeDro, Scopus, and SPORTDiscus. A total of nine randomized controlled trials were included with a sample size of 2,025 subjects (901 ApoE4 carriers). The exercise reported a significant improvement on cognitive perfor-mance in older adults’ ApoE4 noncarriers (standardized mean differ-ence [SMD]=0.653; 95% confidence interval [CI], 0.29–1.00; chi2=35.36; degrees of freedom [df ]=7; P<0.0001; l 2=80%). It was also reported that a total program duration greater than 50 sessions generated differ-ent and significant effects on cognitive performance in older adults’ ApoE4 noncarriers (SMD=0.878; 95% CI, 0.14–1.61; chi2=31.82; df=3; P<0.0001; l 2=91%). The results reported that high intensity generated a differential effect on cognitive performance in older adults’ ApoE4 carri-ers versus noncarriers (SMD=0.963; 95% CI, 0.25–1.67; chi2=18.11; df=3; P<0.0004; l 2=83%). The effect of physical exercise on cognitive perfor-mance in older adults is conditioned by the presence or not of ApoE4.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Search strategy
Criteria for inclusion
Criteria for exclusion
Data extraction
Risk of bias
Data analysis
Meta-analysis
Subgroup analysis
RESULTS
Study selection
Description of studies
Participants’ characteristics
Intervention characteristics
Meta-analysis
DISCUSSION
CONCLUSIONS
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

Apolipoproteins E Exercise Cognition Aged

저자

  • José María Cancela-Carral [ HealthyFit Research Group, University of Vigo, Pontevedra, Spain, Galicia Sur Health Research Institute (IIS Galicia Sur), Sergas-UVIGO, Pontevedra, Spain Faculty of Education and Sports Science, University of Vigo, Pontevedra, Spain ] Corresponding Author
  • Adriana López-Rodríguez [ Galicia Sur Health Research Institute (IIS Galicia Sur), Sergas-UVIGO, Pontevedra, Spain, Faculty of Education and Sports Science, University of Vigo, Pontevedra, Spain ]
  • Irimia Mollinedo-Cardalda [ Galicia Sur Health Research Institute (IIS Galicia Sur), Sergas-UVIGO, Pontevedra, Spain, Faculty of Physiotherapy, University of Vigo, Pontevedra, Spain ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국운동재활학회 [Korean Society of Exercise Rehabilitation]
  • 설립연도
    2004
  • 분야
    의약학>재활의학
  • 소개
    한국운동재활학회는 사회적, 정신적, 신체적 통합건강복지 이론의 학술연구와 회원 상호간 학술교류 증진을 장려함으로써 학문적 발전을 도모하고 나아가 건강복지선진국 발전에 이바지함을 목적으로 한다.

간행물

  • 간행물명
    JER [Journal of Exercise Rehabilitation]
  • 간기
    격월간
  • pISSN
    2288-176X
  • eISSN
    2288-1778
  • 수록기간
    2013~2026
  • 등재여부
    SCOPUS,KCI 등재
  • 십진분류
    KDC 517 DDC 613

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