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Original Article

The effect of synovium graft on conjunctiva in rabbit model of dry eye

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Journal of Animal Reproduction and Biotechnology 바로가기
  • 통권
    Volume. 36 No. 1 (2021.03)바로가기
  • 페이지
    pp.59-68
  • 저자
    Keungjin Park, Kyungmin Nam, Min Jang, Won-Jae Lee, Seong Mok Jeong, Seulgi Bae, Young-Sam Kwon, Sae-Kwang Ku, Sungho Yun
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A393421

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원문정보

초록

영어
This study was performed to identify the effect of synovium graft on conjunctiva in rabbits after dry eye induction. Six New Zealand White rabbits were used as dry eye models. Both eyes were divided to two groups as control and synovium graft group. The synovium graft was performed in fourth week after dry eye modeling. Quantitative change of tears through Schirmer tear test (STT), qualitative change of tear film through tear film break up time (TFBUT), and damage of cornea through fluorescein staining were observed for 10 weeks at intervals of two weeks. Histological examination was performed to evaluate cornea and conjunctiva at tenth week. In both groups, STT and TFBUT were significantly decreased in 4 weeks after modeling compared to 0 weeks (p < 0.05) . After synovium graft, there were increases in STT value at 4 weeks and TFBUT at 4 and 6 weeks in graft group (p < 0.05). Corneal fluorescein staining showed no significant difference between the two groups. In histopathological examination, grafted synovium was detected as round to ovoid ingression folds, well attached to grafted regions with 0.11 ± 0.04 mm2 (range, 0.05- 0.16 mm2). These results indicated that the synovium graft on the conjunctiva had an effect on the qualitative and quantitative improvement of the tear film even though there was no histological change.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Animals
Study design
Dry eye modeling
Clinical examination
Histological process
Histomorphometrical analysis
Statistical analysis
RESULTS
Ophthalmic examinations during inducing dry eye
Ophthalmic examinations after treatment
Histopathological analysis
DISCUSSION
CONCLUSION
CONFLICTS OF INTEREST
AUTHOR CONTRIBUTIONS
AUTHOR’S POSITION AND ORCID NO.

키워드

dry eye keratoconjunctivitis sicca rabbit synovium graft

저자

  • Keungjin Park [ College of Veterinary Medicine, Kyungpook National University ]
  • Kyungmin Nam [ College of Veterinary Medicine, Kyungpook National University ]
  • Min Jang [ College of Veterinary Medicine, Kyungpook National University ]
  • Won-Jae Lee [ College of Veterinary Medicine, Kyungpook National University ]
  • Seong Mok Jeong [ College of Veterinary Medicine, Chungnam National University ]
  • Seulgi Bae [ College of Veterinary Medicine, Kyungpook National University ]
  • Young-Sam Kwon [ College of Veterinary Medicine, Kyungpook National University ]
  • Sae-Kwang Ku [ Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University ]
  • Sungho Yun [ College of Veterinary Medicine, Kyungpook National University ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Journal of Animal Reproduction and Biotechnology
  • 간기
    계간
  • pISSN
    2671-4639
  • eISSN
    2671-4663
  • 수록기간
    2019~2026
  • 십진분류
    KDC 527 DDC 636

이 권호 내 다른 논문 / Journal of Animal Reproduction and Biotechnology Volume. 36 No. 1

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