Earticle

초록

영어

Background: Post-transplant immunosuppression with calcineurin inhibitors (CNIs) is associated with kidney function impairment while mammalian target of rapamycin (mTOR) inhibitors, such as everolimus, can be used for its renal-sparing effects. In this study, we compared the efficacy and safety of everolimus with low dose tacrolimus (EVR+Low TAC) and conventional dose tacrolimus (TAC) in liver transplantation recipients. Methods: Medical records of recipients who received liver transplantation at Seoul National University Bundang Hospital from January 1st 2009 to December 31st 2018 were retrospectively reviewed. Cohort entry date was defined as the day everolimus was initiated and tacrolimus dosage was reduced. All patients were followed up for 1 year. Indicator of efficacy was the incidence of rejection and safety was evaluated by incidence of drug adverse events including renal function. Results: Among 118 patients, there were 40 patients (33.9%) in EVR+Low TAC group. Incidence of rejection, including both biopsy proven acute rejection and clinical rejection, was similar in two groups [7.5% (n=3) vs. 6.4% (n=5), p=1.000]. Renal dysfunction was less frequent in EVR+Low TAC [17.5% (n=7) vs. 35.9% (n=28), p=0.038]. However, incidence rates of dyslipidemia, oral ulcer were more frequent in EVR+Low TAC [45.0% (n=18) vs. 21.8% (n=17), p=0.009; 15.0% (n=6) vs. 1.3% (n=1), p=0.006]. Conclusions: In terms of prevention of rejection, EVR+Low TAC was as effective as TAC and had renal-sparing effect but was associated with increased risk of dyslipidemia and oral ulcer. This study demonstrates that EVR+Low TAC could be an alternative to liver transplant recipients with nephrotoxicity after administration of conventional dose tacrolimus.

목차

ABSTRACT
연구 방법
연구 대상
통계 분석
피험자 보호
연구 결과
대상 환자의 기본 특성
유효성 평가
안전성 평가
고찰
결론
이해상충
참고문헌

키워드

저자

• 장서윤 [ Seoyoun Jang | 분당서울대학교병원 약제부 ]
• 김보람 [ Boram Kim | 분당서울대학교병원 약제부 ]
• 전수정 [ Sujeong Jeon | 분당서울대학교병원 약제부 ]
• 최경숙 [ Kyung Suk Choi | 분당서울대학교병원 약제부 ]
• 이은숙 [ Eunsook Lee | 분당서울대학교병원 약제부 ]
• 이주연 [ Ju-Yeun Lee | 서울대학교 약학대학 ]
• 김은경 [ Euni Lee | 서울대학교 약학대학 ]
• 한호성 [ Ho-Seong Han | 분당서울대학교병원 외과 ]
• 조재영 [ Jai Young Cho | 분당서울대학교병원 외과 ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615