Protective Effect of Diphlorethohydroxycarmalol Isolated from Ishige okamurae against Particulate Matter-Induced Skin Damage by Regulation of NF-B, AP-1, and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts
Lei Wang, Hyun Soo Kim, Jun-Geon Je, Jae Young Oh, Young-Sang Kim, Seon-Heui Cha, You-Jin Jeon
언어
영어(ENG)
URL
https://www.earticle.net/Article/A390095
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원문정보
초록
영어
Particulate matters (PM), the main contributor to air pollution, have become a serious issue that threatens human’s health. Skin is the largest organ in humans, as well as the primary organ exposed to PM. Overexposure of PM induces skin damage. Diphlorethohydroxycarmalol (DPHC), an algal polyphenol with the potential of skin protection, has been isolated from the edible brown seaweed Ishige okamurae. The purpose of the present study is to investigate the protective eect of DPHC against PM (ERM-CZ100)-induced skin damage in human dermal fibroblasts (HDF) cells. The results indicated that DPHC significantly and dose-dependently reduced intracellular reactive oxygen species generation in HDF cells. In addition, DPHC significantly induced collagen synthesis and inhibited collagenase activity in ERM-CZ100-stimulated HDF cells. Further study demonstrated that DPHC remarkably reduced the expression of human matrix metalloproteinases through regulation of nuclear factor kappa B, activator protein 1, and mitogen-activated protein kinases signaling pathways in ERM-CZ100-stimulated HDF cells. This study suggested that DPHC is a potential candidate to protect skins against PM-induced damage, and it could be used as an ingredient in pharmaceutical and cosmeceutical industries.
Lei Wang [ Department of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province 63243, Korea;Marine Science Institute, Jeju National University, Jeju Self-Governing Province 63333, Korea ]
Hyun Soo Kim [ Department of Applied Research, National Marine Biodiversity Institute of Korea ]
Jun-Geon Je [ Department of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province 63243, Korea ]
Jae Young Oh [ Department of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province 63243, Korea ]
Young-Sang Kim [ Department of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province 63243, Korea;Marine Science Institute, Jeju National University, Jeju Self-Governing Province 63333, Korea ]
Seon-Heui Cha [ Department of Marine Bioindustry, Hanseo University ]
Corresponding Author
You-Jin Jeon [ Department of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province 63243, Korea;Marine Science Institute, Jeju National University, Jeju Self-Governing Province 63333, Korea ]
Corresponding Author
제주대학교 해양과학연구소 [Marine Science Institute Jeju National University]
설립연도
1968
분야
농수해양>수산학
소개
해양의 실체와 그 자원의 합리적 이용과 관리방법을 규명하기 위하여 해양물리, 화학, 생물, 지질, 공학등 여러 관련분야에 관한 다양한 연구를 수행하며, 환경의 보전과 보호를 위해서 수질, 대기, 상·하수도, 폐기물, 사회적 환경 등의 연구를 통하여 쾌적하고 청정한 환경을 보전하기 위한 다양한 연구를 수행하고, 또한 해양 및 환경분야의 우수한 인력양성, 국내외 학술교류의 증진, 학·산 협동체제의 확립 등을 통하여 해양과 환경에 관한 기초 및 응용적 학술연구를 종합적으로 수행함을 목적으로 한다.
간행물
간행물명
해양과학연구소 연구논문집 [Bulletin of the Marine Science Institute]