Earticle

초록

영어

One purpose of this study was to develop and validate a quantitative LC-MS/MS method for the analysis of vortioxetine and its carboxylic acid metabolite, and the other purpose is to obtain a therapeutic range of vortioxetine by applying it to the plasma of the actual medicine takers. The targetcompounds were measured with liquid chromatography-tandem mass spectrometry (LC-MS/MS) after deproteination. The LC system was coupled to a 4500 QTrap mass spectrometer using electrospray ionization in positive mode and multiple reaction monitoring (MRM) mode. The column was Kinetex XBC18 column. The method showed acceptable precision and accuracy, which were less than 12%, as well as satisfactory matrix effects and recoveries. The concentrations of vortioxetine and carboxylic acid of vortioxetine in plasma of the actual medicine takers were 3.23 ng/mL ~ 63.8 ng/mL and 3.63 ng/mL ~ 46.9 ng/mL, respectively. In conclusion, this LC-MS/MS method can be a sensitive and specific protocol for determining vortioxetine and its carboxylic acid metabolite in human plasma. Also vortioxetine concentration results of actual medicine takers can be considered as a good reference when evaluating vortioxetine toxicity.

목차

Abstract
I. 서론
II. 실험방법
1. 시약 및 재료
2. 표준시료 조제 및 시료 전처리
3. 분석기기 및 조건
4. 시험방법의 유효화
5. 분석대상시료 선정
III. 결과 및 고찰
1. 시험방법의 유효화
2. 실제 치료목적 복용자의 혈장 중 농도
IV. 결론
V. 참고문헌

키워드

저자

• 우상희 [ Sanghee Woo | 대구과학수사연구소 법독성화학과 ] Corresponding Author
• 김소현 [ So-Hyun Kim | 서울과학수사연구소 법독성화학과 ]
• 김재욱 [ Jaeook Kim | 대구과학수사연구소 법독성화학과 ]
• 이호선 [ Ho-Sun Lee | 대구과학수사연구소 법독성화학과 ]
• 이상기 [ Sangki Lee | 대구과학수사연구소 법독성화학과 ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국법과학회지 [Korean Journal of Forensic Science]

• 간기

  반년간

• pISSN

  1598-0715

• 수록기간

  2000~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 367 DDC 347