Earticle

초록

영어

Maternal nutrition is necessary for the growth of the fetus, and exces-sive intake of nutrients interferes with brain development in offspring. In the current study, the effect of treadmill running during pregnancy in obese maternal rats on spatial learning memory and spatial working memory in rat pups was investigated. Phosphorylation of phosphatidyli-nositol 3-kinase (PI3K), protein kinase B (Akt), and extracellular sig-nal-regulated kinase 1 and 2 (ERK1/2) was also identified in rat pups. Female rats were divided into the normal diet group and the high-fat diet group for 7 weeks, including pregnancy and lactation. Maternal treadmill running was performed for 4 weeks. The born rat pups were classified into a control group, a treadmill exercise group, a high-fat diet group, a high-fat diet and treadmill exercise group according to the sta-tus of maternal rats. Radial 8-arm maze task for spatial learning memory and Morris water maze task for spatial working memory were done. Western blot analysis was conducted to determine the expressions of PI3K, Akt, ERK1/2. In the current results, maternal treadmill running during pregnancy improved spatial learning memory and spatial work-ing memory in rat pups born to obese maternal rats. This improving ef-fect of memory was due to the enhanced phosphorylation of PI3K, Akt, and ERK1/2 by treadmill running.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals
Radial 8-arm maze task
Morris water maze task
Tissue preparation
Western blot analysis
Data analysis
RESULTS
Spatial learning ability
Spatial working memory
PI3K expression
Akt expression
ERK1/2 expression
DISCUSSION
CONFLICT OF INTEREST
REFERENCES

키워드

저자

• Young Jun Ko [ Major in Sport Service Practice, College of Welfare Convergence, Kangnam University, Yongin, Korea ]
• Bo-Kyun Kim [ Department of Emergency Technology, College of Health Science, Gachon University, Incheon, Korea ]
• Eun-Sang Ji [ Department of Sport & Health Care, College of Art & Culture, Sangmyung University, Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613