Earticle

초록

영어

Ginger (Zingiber officinale Rosc.) has widely used for the digestive in Korea and is the most popular food spices with a uniquely pungent flavor. Many compounds have been isolated in ginger, such as gingerols, steroids, monoterpenoids, etc. Many studies have reported the bioactivity of ginger extracts and active compounds in ginger such as antioxidant, anti-inflammatory, anti-cancer, and effect on the cardiovascular systems. However, the pharmacological effects of ginger between multiple-compounds and multiple-target were not reported yet. So, we confirmed the holistic pharmacological effect of ginger using a network pharmacology approach. We screened through six compounds (6-gingerol, 6-shogaol, dihydrocapsaicin, poriferastan-3β-ol, β-sitosterol, and stigmasterol) with ADME screening in the TCMSP database and searched 55 genes linked to six active compounds using the STITCH database. The core potential target genes were TP53, BCL2, MAPK8, HSP90AA1, and CYP7AA1. And Functional analysis of target genes was performed through Annotation, Visualization, and Integrated Discovery (DAVID) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway databases; 64 pathways were searched. Among them, pathways related to infectious disease were found the most. Therefore, this study was demonstrated the multi-component, multi-target, and multi-pathway characteristics of ginger, which were able to predict various efficacy properties for ginger compounds.

목차

Abstract
서론
본론
1. 실험방법
2. 실험결과 및 고찰
3. 고찰
결론
감사의 글
참고문헌

키워드

저자

• 이아영 [ A Yeong Lee | 한국한의학연구원 한약자원연구센터 책임연구원 ]
• 이준 [ Jun Lee | 한국한의학연구원 한약자원연구센터 책임연구원 ]
• 천진미 [ Jin Mi Chun | 한국한의학연구원 한약자원연구센터 선임연구원 ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한약정보연구회지 [Korean Herbal Medicine Informatics]

• 간기

  반년간

• pISSN

  2288-5161

• eISSN

  2288-5293

• 수록기간

  2013~2025

• 십진분류

  KDC 519 DDC 610