Earticle

초록

영어

Maternal obesity is known to increase the likelihood of offspring be-coming obese, high blood pressure, and other metabolic disorders. Af-ter inducing obesity, the effect of treadmill exercise in maternal rats during pregnancy on short-term memory was investigated in relation to neurogenesis in rat pups. Short-term memory was declined in rat pups born to obese maternal rats, and treadmill running during pregnancy al-leviated short-term memory impairment in rat pups born to obese ma-ternal rats. The number of doublecortin (DCX)-positive and 5-bro-mo-2′-deoxyuridine (BrdU)-positive cells in the hippocampal dentate gyrus was decreased in rat pups born to obese maternal rats. Treadmill running during pregnancy increased the number of DCX-positive and BrdU-positive cells in rat pups born to obese maternal rats. Expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) in the hippocampus was decreased in the rat pups born to obese maternal rats. Treadmill running during pregnancy increased the ex-pressions of BDNF and TrkB in rat pups born to obese maternal rats. Enhancing effect of short-term memory by treadmill exercise may be due to increased neurogenesis through activation of the BDNF-TrkB signaling pathway by treadmill exercise.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals
Treadmill exercise protocol and BrdU injection
Step-down avoidance task
Tissue preparation
Immunohistochemistry for DCX
Immunohistochemistry for BrdU
Western blot analysis
Data analysis
RESULTS
Short-term memory
Number of DCX-positive cells
Number of BrdU-positive cells
BDNF and TrkB expression
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Eun-Sang Ji [ Department of Sport & Health Care, College of Art & Culture, Sangmyung University, Seoul, Korea, Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• You-Mi Kim [ Sports Science Research Institution, Korea National Sport University, Seoul, Korea ]
• Young Jun Ko [ Major in Sport Service Practice, College of Welfare Convergence, Kangnam University, Yongin, Korea ]
• Seung-Soo Baek [ Major in Sport Service Practice, College of Welfare Convergence, Kangnam University, Yongin, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613