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Original Article

노인 치매 환자의 항정신병약물 및 항파킨슨약물 처방 현황
The Prescribing Patterns of Antipsychotic Drugs and Antiparkinsonian Drugs in Elderly Patients with Dementia

첫 페이지 보기
  • 발행기관
    한국임상약학회 바로가기
  • 간행물
    한국임상약학회지 KCI 등재 바로가기
  • 통권
    제30권 제2호 (2020.06)바로가기
  • 페이지
    pp.81-86
  • 저자
    윤수미, 이승원, 장지은, 이영숙, 유기연
  • 언어
    한국어(KOR)
  • URL
    https://www.earticle.net/Article/A378207

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원문정보

초록

영어
Background: The number of patients with dementia continues to increase as the age of aging continues to grow. Psychiatric symptoms caused by senile dementia are controlled using antipsychotics. However, these antipsychotics can lead to Parkinson's disease, and abuse of dopamine derivatives such as levodopa among Parkinsonian drugs can lead to psychosis. Therefore, we evaluated the patterns of prescribed antipsychotics and antiparkinsonian drugs in patients with senile dementia. Methods: We used data from the sample of elderly patients from the Health Insurance Review and Assessment Service (HIRA-APS-2016). We analyzed the patterns of prescribing antipsychotics and antiparkinsonian drugs including prescribed daily dosage, period of prescription, and number of patients with both antipsychotics and antiparkinsonian drugs for senile dementia. Results: Among the 159,391 patients with dementia included in this analysis, 4,963 patients (3.1%) and 16,499 patients (10.4%) were prescribed typical and atypical antipsychotic drugs, respectively. The most frequently prescribed typical antipsychotic was haloperidol (4,351 patients with dementia), whereas the atypical agent was quetiapine (12,719 patients). The most frequently prescribed antiparkinsonian drugs were in the order of levodopa/carbidopa, benztropine, and ropinirole. In addition, 1,103 and 3,508 patients prescribed typical and atypical antipsychotics, respectively, were co-prescribed antiparkinsonian drugs. Conclusions: Atypical antipsychotics were the preferred prescription in patients with senile dementia. The prescription dose was relatively low; however, the average treatment duration was mostly long-term. Selection of antipsychotics and/or antiparkinsonian drugs should be made carefully in senile dementia and the causal relationship of adverse drug reactions needs further study.

목차

ABSTRACT
연구 방법
분석 자료
대상 질환 및 약물 정의
통계 분석
연구 결과
대상 환자 특성
항정신병약물 처방 분석
항파킨슨약물 처방 분석
고찰 및 결론
참고문헌

키워드

Dementia antipsychotics antiparkinsonian drug elderly patients

저자

  • 윤수미 [ Soo Mi Yoon | 동덕여자대학교 약학대학 ]
  • 이승원 [ Sungwon Lee | 연세대학교 의과대학 정신과학교실 ]
  • 장지은 [ Ji-Eun Chang | 동덕여자대학교 약학대학 ]
  • 이영숙 [ Young Sook Lee | 계명대학교 약학대학 ]
  • 유기연 [ Kiyon Rhew | 동덕여자대학교 약학대학 ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국임상약학회 [Korean College of Clinical Pharmacy]
  • 설립연도
    1
  • 분야
    의약학>약학
  • 소개
    합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.

간행물

  • 간행물명
    한국임상약학회지 [Korean Journal of Clinical Pharmacy]
  • 간기
    계간
  • pISSN
    1226-6051
  • 수록기간
    1991~2026
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 518 DDC 615

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