Earticle

초록

영어

There is a strong connection between the diet rich in antioxidants and the decreased incidence of inflammatory bowel disease and cancerous diseases. Diets that are rich in anti-oxidants particularly include fruits and vegetables containing the high amounts of vitamin A-E, carotenoids, and minerals. The supercritical heat-treated radish extracts of the research result had an inhibitory effect on the development of aberrant crypt foci (ACF), namely, preneoplastic lesions having a potential to become cancer cells and reduced the number of the aberrant crypt foci (ACF) consisting of four or more aberrant crypts (AC) having high risk to become tumors by about half. The supercritical heat-treated radish extracts can reduce the incidence of preneoplastic lesions having a high risk of developing cancer by about 28 %. DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. Supercritical heat-treated radish extracts, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, supercritical heat-treated radish extracts treatment significantly reduced the expression of pro-inflammatory signaling molecules through suppression both mitogen-activated protein kinases (MAPK) and nuclear factorkappa B (NF-kB) signaling pathways, and prevented the apoptosis of colon. Moreover, supercritical heattreated radish extracts administration significantly led to the up-regulation of anti-oxidant enzyme including SOD and Catalase.

목차

Abstract
1. Introduction
2. Experiment Materials and Methods
2.1 Preparation of Processed Extract
2.2 Assessment of inhibitory efficacy on colon cancer
2.3 Examination of preneoplastic lesions for colon cancer
2.4 Experimental animals and induction of colitis
2.5 Measurement of ROS level in the serum
2.6 Preparation of cytosol and nuclear fractions
2.7 Immunoblotting analyses
2.8 Hematoxylin and eosin (H/E) stain of colon tissue
2.9 Statistical analysis
3. Result and Discussion
3.1 Clinical sign, body weight and water intake
3.2 Body weight and organ weight
3.3 Examination of preneoplastic lesions for colon cancer
3.4 Effect of supercritical heat-treated radish extract(SRE) on the Expression of ROS and NADPH Oxidase in Serum.
3.5 ROS overexpression activates MAPK including p-p38 and p-ERK and NF-κB
3.6 Pro-inflammatory
3.7 Apoptosis
5. Conclusion
Acknowledgments
References

키워드

저자

• Hyun-Kyoung Kim [ Department of Food Science and Engineering, Seowon University, Cheongju, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  International Journal of Internet, Broadcasting and Communication

• 간기

  계간

• pISSN

  2288-4920

• eISSN

  2288-4939

• 수록기간

  2009~2025

• 십진분류

  KDC 326 DDC 380