Earticle

초록

영어

As blood flow is proportional to the fourth power of the vascular radius small changes in the diameter of resistance arteries/arterioles following an increase in intraluminal pressure would be expected to substantially increase blood flow. However, arteriolar myocytes display an intrinsic ability to locally regulate blood flow according to metabolic demands by tuning the diameter of small arteries in response to local changes in he-modynamics. Critical to this, observations were made more than 100 years ago that mechanosensitive small arteries exhibit the “myogenic response” or pressure-induced vasoconstriction or vasodilation in re-sponse to increased or decreased intravascular pressure, respectively. Although cellular mechanisms underlying the myogenic response have now been studied extensively, the precise cellular mechanisms under-lying this intriguing phenomenon still remain uncertain. In particular, the biological machinery that senses changes in intravascular pressure in vascular smooth muscle cells have not been unquestionably identified and remain a significant issue in vascular biology to be fully elucidated. As such, this brief review focuses on putative mechanosensors that have been proposed to contribute to myogenic vasoreactivity. Specific attention is paid to the roles of integrins, G protein-coupled receptors, and cadherins.

목차

Abstract
INTRODUCTION
ROLES OF INTEGRINS AND CADHERINS IN MYOGENIC CONSTRICTION
INVOLVEMENT OF MECHANOSENSITIVE GPCR IN MYOGENIC CONSTRICTION
CONCLUSIONS
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Kwang-Seok Hong [ Department of Physical Education, College of Education, Chung-Ang University, Seoul, Korea ] Corresponding Author
• Kijeong Kim [ School of Exercise & Sport Science, College of Natural Sciences, University of Ulsan, Ulsan, Korea ]
• Michael A. Hill [ Dalton Cardiovascular Research Center, University of Missouri-School of Medicine, Columbia, MO, USA, Department of Medical Pharmacology and Physiology, University of Missouri-School of Medicine, Columbia, MO, USA ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613