Earticle

초록

영어

Social isolation during adolescence is associated with anxiety, depres-sion, and memory impairment. Exercise has been reported as a positive effect on brain function, especially hippocampus. The present study ex-amined the effect of swimming exercise on apoptosis, cell proliferation, and serotonin expression in social isolation rats during adolescence stage. Social isolation started at postnatal day 21 and continued for 6 weeks. The rats in the swimming group were forced to swim for 60 min once daily during 6 days per week for 6 consecutive weeks. The rats in the social isolation during adolescence showed anxiety, depression, short-term memory impairment. Social isolation facilitated apoptosis and inhibited cell proliferation and differentiation. Social isolation sup-pressed expression of serotonin, brain-derived neurotrophic factor, and tyrosine kinase B. Swimming exercise alleviated anxiety, depression, short-term impairment. Swimming exercise suppressed apoptosis, en-hanced neurogenesis, and increased serotonin expression. In our study, swimming exercise ameliorates mood disorder and memory impairment by enhancing neurogenesis and serotonin expression and inhibiting apoptosis in social isolation.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experiment animals
Swimming exercise protocol
Elevated plus-maze test
Forced swimming test
Step-through avoidance test
Tissue preparation
Immunohistochemistry for TPH, 5-HT in dorsal raphe
Immunohistochemistry for BrdU
Immunohistochemistry for DCX
TUNEL staining
Western blotting for BDNF, TrkB, Bax, and Bcl-2
Data analysis
RESULTS
Effect of swimming exercise on anxiety, depression, and short-term memory
Effect of swimming exercise on apoptosis in the hippocampus
Effect of swimming exercise on BDNF and TrkB expression in the hippocampus
Effect of swimming exercise on cell proliferation and differentiation in hippocampal dentate gyrus
Effect of exercise on TPH and 5-HT in the dorsal raphe
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Hye-Sang Park [ Department of Kinesiology, College of Public Health and Cardiovascular Research Center, Lewis Katz school of Medicine, Temple University, Philadelphia, PA, USA ]
• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea, Exercise Rehabilitation Research Institute, Department of Exercise & Health Science, Sangmyung University, Seoul, Korea ]
• Sang-Seo Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sam-Jun Lee [ Department of Sport Rehabiliation, Tongmyong University, Busan, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613