Earticle

초록

영어

Background: Prevention of osteoporosis and bone fracture is one of the important issues for liver transplant recipients because a long history of liver disease and lifelong use of immunosuppressants, including corticosteroids, may cause these diseases. In this study, we aimed to analyze liver recipient bone status, 10-year fracture risk, and medication history. Methods: The electronic medical records of adult patients aged >40 years who received liver transplantation at Seoul National University Bundang Hospital between January 2009 and June 2017 were reviewed retrospectively. On the basis of their bone mineral density and fracture history, their fracture risks were analyzed using the Korean fracture risk assessment tool. Results: A total of 57 liver transplant recipients were treated with corticosteroids during a mean of 8.8 months after transplantation. 30 patients (52.6%) showed bone metabolism dysfunction such as osteopenia or osteoporosis. The 10-year femoral fracture risk was 2.1%, and dual-energy X-ray absorptiometry monitoring was performed, including right before liver transplantation every 27.5±19.2 months. The mean femoral bone mineral density decreased by −7.2%±7.3%. Four patients (7.0%) had a fracture after liver transplantation. Osteoporotic fracture occurred in 3 patients with osteoporosis (25.0%). Among the osteopenia patients with moderate fracture risk who were not treated with bisphosphonate, 1 patient (12.5%) had a history of bone fracture after liver transplantation. Conclusions: Considering the deterioration of bone density and moderate fracture risk, medication for osteoporosis should be prescribed to liver transplant recipients with regular monitoring of bone density after transplantation.

목차

ABSTRACT
연구방법
연구대상
자료 수집 및 분석 방법
연구 대상자 보호
연구 결과
연구 대상의 일반적 특성
간 이식 전 골질환 유병률 및 10년 내 골절위험도
간 이식 전후 골밀도 변화 및 골절
간 이식 전후 골다공증 관련 약제 투여
고찰
결론
이해상충
참고문헌

키워드

저자

• 최호정 [ Hojeong Choi | 분당서울대학교병원 약제부 ]
• 김보람 [ Boram Kim | 분당서울대학교병원 약제부 ]
• 김윤희 [ Yoonhee Kim | 분당서울대학교병원 약제부 ]
• 이정화 [ Jungwha Lee | 분당서울대학교병원 약제부 ]
• 이은숙 [ Eunsook Lee | 분당서울대학교병원 약제부 ]
• 김은경 [ Euni Kim | 서울대학교 약학대학 ]
• 조재영 [ Jai Young Cho | 분당서울대학교병원 외과 ]
• 최영록 [ YoungRok Choi | 서울대학교병원 외과 ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615