Purpose: Norepinephrine (NE) is a neurotransmitter of the sympathetic nervous system. It is used for treating hypotension on distributive shock, central nervous system injury, or sepsis. There are several reports that state that alcohol suppresses vasoconstriction by NE. Thus, our hypothesis is that the effect of NE is reduced in alcohol-drinking patients with distributive shock. We investigated whether alcohol suppresses NE-induced contraction and aimed at finding a solution to this problem. Methods: For this study, we used the aorta from male Sprague-Dawley rats (9-11 weeks) and an isometric contraction system. Results: Our results showed that alcohol suppresses NE contraction and does not affect epinephrine induced a contraction. Moreover, in the presence of alcohol, a 7:3 mixture of NE and epinephrine induced a contractile force similar to that induced by NE under normal conditions. Conclusion: We found that the vasoconstrictive force of NE decreased in the blood vessels in which alcohol was present, which was not because endothelial cells. The reduced contractile force was most similar to that induced by a 7:3 mixture of NE and epinephrine.
목차
Abstract Ⅰ. 서론 Ⅱ. 연구방법 1. 연구설계 2. 연구대상 3. 윤리적 고려 4. 연구도구 5. 분석방법 Ⅲ. 연구결과 1. 노르에피네프린에 의한 혈관 수축력비교 2. 에피네프린에 의한 혈관 수축력 비교 3. 노르에피네프린과 에피네프린 혼합물비교 Ⅳ. 고찰 Ⅴ. 결론 ORCID ID References
키워드
AlcoholEpinephrineNorepinephrineShock
저자
강명신 [ Myeongsin Kang | 을지대학교 응급구조학과, 서울대학교 병원 응급의학과 ]
한국응급구조학회 [The Korean Society of Emergency Medical Technology]
설립연도
1997
분야
의약학>응급의학
소개
복합 구조적인 산업사회의 발전에 따라 안전사고와 응급상황에서의 구조구급요청자들이 증가하고 있으나 우리나라의 응급의료체계는 아직 그 수준을 따라가지 못하고 있는 실정이다. 이에 우리나라의 응급의료체계를 확립하고 구조구급에 관한 기초학문의 발전에 기여하고자 학회를 창립한다.
간행물
간행물명
한국응급구조학회지(구 한국응급구조학회논문지) [The Korean Journal of Emergency Medical Services ]