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Transcriptional Properties of the BMP, TGF-B, RTK, Wnt, Hh, Notch, and JAK/STAT Signaling Molecules in Mouse Embryonic Stem Cells

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Reproductive & developmental biology 바로가기
  • 통권
    Volume 30 No 2 (2006.06)바로가기
  • 페이지
    pp.143-156
  • 저자
    Jeung-Yon Rho, Gab-Yong Bae, Jung-Il Chae, Kweon Yu, Deog-Bon Koo, Kyung-Kwang Lee, Yong-Mahn Han
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A36261

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원문정보

초록

영어
Major characteristics of embryonic stem cells (ESCs) are sustaining of stemness and pluripotency by self-renewal. In this report, transcriptional profiles of the molecules in the developmentally important signaling pathways including Wnt, BMP4, TGF-β, RTK, Hh, Notch, and JAK/STAT signaling pathways were investigated to understand the self- renewal of mouse ESCs (mESCs), J1 line, and compared with the NIH3T3 cell line and mouse embryonic fibroblast (MEF) cells as controls. In the Wnt signaling pathway, the expression of Wnt3 was seen widely in mESCs, suggesting that the ligand may be an important regulator for self-renewal in mESCs. In the Hh signaling pathway, the expression of Gli and N-myc were observed extensively in mESCs, whereas the expression levels of in a Shh was low, suggesting that intracellular molecules may be essential for the self-renewal of mESCs. IGF-I, IGF-II, IGF-IR and IGF-IIR of RTK signaling showed a lower expression in mESCs, these molecules related to embryo development may be restrained in mESCs. The expression levels of the Delta and HES5 in Notch signaling were enriched in mESCs. The expression of the molecules related to BMP and JAK-STAT signaling pathways were similar or at a slightly lower level in mESCs compared to those in MEF and NIH3T3 cells. It is suggested that the observed differences in gene expression profiles among the signaling pathways may contribute to the self-renewal and differentiation of mESCs in a signaling-specific manner.

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

키워드

Embryonic stem cells Signaling pathways Self-renewal Differentiation Transcription

저자

  • Jeung-Yon Rho [ Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB) ]
  • Gab-Yong Bae [ Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB) ]
  • Jung-Il Chae [ Jung-Il Cgae | Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB) ]
  • Kweon Yu [ Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB) ]
  • Deog-Bon Koo [ Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB) ]
  • Kyung-Kwang Lee [ Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB) ]
  • Yong-Mahn Han [ Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB) ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Reproductive & developmental biology
  • 간기
    계간
  • pISSN
    1738-2432
  • eISSN
    2288-0151
  • 수록기간
    1977~2018
  • 십진분류
    KDC 527 DDC 636

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