Earticle

초록

영어

Background: Hypercalcemia is an important metabolic emergency condition in cancer patients. Bisphosphonate is the treatment of choice for hypercalcemia, whereas calcitonin and hydration with furosemide are recommended for acute supportive therapy. However, data regarding real-world treatment patterns and outcomes of pharmacological treatments are limited. Therefore, we aimed to investigate the treatment patterns and clinical outcomes of hypercalcemia treatment in solid tumor patients. Methods: Electronic medical records of 123 adults with solid cancers and albumin-corrected calcium levels >10.5 mg/dL or ionized calcium levels >1.35 mmol/L were reviewed. We retrospectively analyzed the pharmacological treatment and recovery rate according to the severity of hypercalcemia. Results: A total of 177 cases were identified, of which 49 were not treated and 30 were treated with hydration only. In moderate-to-severe cases, 86.5% received pharmacological treatment. Thirty-four cases (19.2%) were treated with bisphosphonate alone and 58 cases (32.8%) were treated with bisphosphonate and calcitonin. In mild hypercalcemia cases, the recovery rate was higher for those receiving hydration only or pharmacological treatment (79.7%) than for those receiving no treatment (61.4%, p = 0.041). Most moderate-to-severe cases were treated with medication and of those treated, 56.3% recovered. The recovery rate was lower in those treated with bisphosphonate alone (38.2%) than in those who underwent calcitonin combination treatment (73.7%, p = 0.001). Conclusions: Bisphosphonate combined with calcitonin was found to be more effective than bisphosphonate alone for the treatment of moderate-to-severe hypercalcemia. Considering the current shortage of calcitonin, further efforts are required to ensure its stable supply.

목차

ABSTRACT
연구방법
자료 수집 및 변수 정의
통계분석
연구 결과
치료현황
고칼슘혈증 중증도별 약물 치료 효과
고찰
결론
참고문헌

키워드

저자

• 신다은 [ Da Eun Shin | 서울대학교병원 약제부 ]
• 박설희 [ Seol Hee Park | 서울대학교병원 약제부 ]
• 김성환 [ Sung Hwan Kim | 서울대학교병원 약제부 ]
• 서성연 [ Sung Yun Suh | 서울대학교병원 약제부 ]
• 조윤희 [ Yun Hee Jo | 서울대학교병원 약제부 ]
• 조윤숙 [ Yoon Sook Cho | 서울대학교병원 약제부 ]
• 임석아 [ Seock-Ah Im | 서울대학교 의과대학 내과학 교실, 서울대학교 암연구소, 서울대학교병원 내과 ] Corresponding author
• 이주연 [ Ju-Yeun Lee | 서울대학교 약학대학 및 종합약학연구소 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615