Earticle

초록

영어

In general, exercise can help improve overall health and prevent dis-eases. However, individuals with atopic dermatitis (AD) often lose the desire for physical exercise owing to itching caused by sweating. In the present study, we have evaluated the effect of low-intensity tower climbing resistance exercise (TCRE) on Dermatophagoides farinae ex-tract (DFE; house dust mite extract)- and 2,4-dinitrochlorobenzene-in-duced AD-like skin lesions in a BALB/c model. Histopathological exam-ination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells in the ears. TCRE downregulated serum Ig levels and suppressed mRNA expression of pro-inflammatory cyto-kines in the ear tissue, and reduced the size and weight of draining lymph nodes (dLNs) and nondraining lymph nodes (ndLNs), along with expres-sion of pro-inflammatory cytokines in CD4+ T cells from dLNs and ndLNs. Taken together, we showed that low-intensity TCRE reduced AD symp-toms. These results will help improve treatment of AD, and will be of in-terest to dermatologists as well as to patients with AD.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Materials
Animals
Induction of AD lesions in the ear and TCRE protocol
Ear thickness measurement and blood sample preparation
Histological observations
Real-time polymerase chain reaction
Statistical analysis
RESULTS
Effect of TCRE on the ear thickness and histopathological observation and on serum Ig levels
Effect of TCRE on the expression of variouspro-inflammatory cytokines in vivo
DISCUSSION
CONFLICT OF INTEREST
REFERENCES

키워드

저자

• Jooyoung Kim [ Department of Anatomy, School of Medicine, Kyungpook National University, Daegu, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613