Earticle

초록

영어

Traumatic brain injury (TBI) causes a variety of neuropathological mani-festations including cognitive, emotional, physiological and psychologi-cal deficits. Physical exercise is known to ameliorate neurological im-pairments induced by various brain injuries. We investigated the effects of treadmill exercise on memory impairments due to TBI in relation to dopamine and D2 dopamine receptor. TBI was induced with an electro-magnetic-controlled cortical impact device. The rats in the exercise groups were scheduled to run on a treadmill for 30 min once a day for 28 days after TBI induction. Then, step-down avoidance task, radial 8-arm maze test, immunohistochemistry for tyrosine hydroxylase (TH), and western blot for D2 dopamine receptor were performed. TBI im-paired short-term and spatial learning memories. TBI decreased TH ex-pressions in the prefrontal cortex (PFC), striatum, hippocampus dentate gyrus, and substantia nigra (SN). By contrast, the expressions of D2 do-pamine receptor in the PFC, striatum, hippocampus, and SN were in-creased by TBI. Treadmill exercise alleviated the impairments of short-term and spatial learning memories observed in TBI rats. TH expression was decreased and D2 dopamine receptor expression was increased in TBI rats. Treadmill exercise enhanced TH expression and suppressed D2 dopamine receptor expression in TBI rats. TBI deteriorated short-term and spatial learning memories, in contrast, treadmill exercise alle-viated the TBI-induced memory impairments by up-regulating dopa-mine level and down-regulating D2 dopamine receptor expression.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals and treatments
Induction of TBI
Exercise protocol
Step-down avoidance task
Radial 8-arm maze test
Tissue preparation
Immunohistochemistry for TH
Western blotting
Data analysis
RESULTS
Effects of treadmill exercise on the short-term memory
Effects of treadmill exercise on the spatial learning memory
Effects of treadmill exercise on TH expressions
Effects of treadmill exercise on D2 dopamine receptor expressions
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Il-Gyu Ko [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Hong Kim [ Department of Oriental Sports Medicine, College of Biomedical Science, Daegu Haany University, Gyeongsan, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613