Earticle

초록

영어

Atopic dermatitis (AD) is chronic relapsing skin inflammatory allergic disease characterized by a complex pathogenesis including skin barrier dysfunction, immune-redox disturbances and pruritus. Topical treatment medications such as corticosteroids, calcineurin inhibitors, T-cell inhibitors were used in AD but these agents may have some potential side-effects. Therefore, many researchers explored abundant numbers of alternative therapies by using natural products and mineral compounds related with its antioxidant and immunomodulator effects to minimize toxicity and adverse-effects. In the present study, we investigated the effects of mineral complex material patch (MCM) treatment on AD-like lesions in 2, 4-dinitrochlorobenzene (DNCB)-induced hairless mice. Animals were divided into four groups; normal control, negative control (DNCB Only), DNCB+ Tacrolimus (PC) and DNCB+MCM patch to evaluate its therapeutic effect on DNCB-induced AD. Our results showed that MCM patch improved the skin dermatitis by significantly increasing the skin barrier strength, score and moisture level and decreasing the transepidermal water loss as compared to DNCB only group. In line, ROS level, inflammatory, Th1 and Th2 cytokines were decreased with MCM treatment whereas nitric oxide level and total anti-oxidant enzyme activities were significantly enhanced as compared to DNCB only and NC groups. Moreover, total IgE level was significantly increased in DNCB only group and decreased in PC and MCM treated group. Taken together, our findings suggest that MCM may potentially protect against AD lesional skin via regulation of skin barrier function and immune-redox response. However, further studies are needed to explain the detail molecular mechanism of MCM effect.

키워드

저자

• Johny Bajgai [ Department of Environmental Medical Biology, Department of Global Medical Science ]
• Cheol-Su Kim [ Department of Environmental Medical Biology, Department of Microbiology, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Republic of Korea ]
• Ailyn Fadriquela [ Department of Environmental Medical Biology, Department of Global Medical Science ]
• Rahima Begum [ Department of Environmental Medical Biology, Department of Global Medical Science ]
• Xingyu Jing [ Department of Environmental Medical Biology, Department of Global Medical Science ]
• Dong Heui Kim [ Department of Environmental Medical Biology ]
• Soo-Ki Kim [ Department of Microbiology, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Republic of Korea ]
• Kyu-Jae Lee [ Department of Environmental Medical Biology, Institute for Poverty Alleviation and International Development, Yonsei University, Wonju Campus, Wonju, Gangwon-do 26493, Republic of Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국물학회지 [Korean Journal of Waters]

• 간기

  부정기

• pISSN

  2233-4653

• 수록기간

  2010~2021

• 십진분류

  KDC 539 DDC 628