Earticle

초록

영어

Hydrogen water (HW) which is produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on dementia that is associated with cognitive impairment and memory loss, is poorly documented. In the present study, we investigated the drinking effects of hydrogen water on dementia patient for prevention through oxidative stress and immuno redox mechanism. Dementia patients were administered with HW and purified water (PW) for 6 months. Further, we evaluated hydrogen water effect on the cognitive impairment by checking the serum concentration of Alzheimer's disease (AD) biomarkers [Amyloid β (Aβ) 40, Aβ 42 and tau], inflammatory cytokines such as IL-1β, IL-6, IL-13, TNF-α, IL-10 and IL-4, Th1/Th2 cytokines such as IL-2, IFN-γ, IL-12p70 and IL-5, reactive oxygen species (ROS), and nitric oxide (NO) levels. We found that HW treatment significantly decreased the serum level of Aβ 40 after 6 mon of treatment. In parallel, inflammatory cytokines were significantly inhibited in experimental group compared to control group. In line, Th1/Th2 cytokines were significantly decreased in HW than PW group. Furthermore, oxidative stress markers such as ROS and nitric oxide level were decreased in HW treated group than PW control group. Overall our clinical results strongly recommended that drinking hydrogen water might be a promising preventative approach for age-related neurodegenerative disease like dementia and have an enormous impact on future healthcare for the elderly patients. This might be the first note on the clinical application of drinking HW on the serum of dementia patients.

목차

ABSTRACT
Introduction
Materials and Methods
1. Preparation of control water
2. Preparation of experimental water
3. Participants
4. Study design
5. Blood sampling
6. Measurement of AD dementia marker and cytokine measurement
7. Determination of total ROS level
8. Determination of nitric oxide (NO)
9. Data management and analysis
Results
1. Effects of HW drinking on dementia/AD biomarkers on dementia patients
2. Drinking effects of HW on dementia/AD on pro and anti-inflammatory cytokines on dementia patients
3. Effects of HW drinking on dementia/AD on Th1/Th2 cytokine on dementia patients
4. Effects of HW drinking on dementia/AD on anti-inflammatory cytokine on dementia patients
5. Effects of HW drinking on dementia/AD on total ROS and NO level on dementia patients
Discussion
Acknowledgements
Conflict of Interest
References

키워드

저자

• Johny Bajgai [ Department of Environmental Medical Biology, Yonsei University Wonju College of Medicine, Wonju, Gangwon 26427, Republic of Korea ]
• Jeong Eunsook [ Department of Environmental Medical Biology, Yonsei University Wonju College of Medicine, Wonju, Gangwon 26427, Republic of Korea ]
• Cheol Su Kim [ Department of Environmental Medical Biology, Yonsei University Wonju College of Medicine, Wonju, Gangwon 26427, Republic of Korea ]
• Ailyn Fadriquela [ Department of Environmental Medical Biology, Yonsei University Wonju College of Medicine, Wonju, Gangwon 26427, Republic of Korea ]
• Dong-Heui Kim [ Department of Environmental Medical Biology, Yonsei University Wonju College of Medicine, Wonju, Gangwon 26427, Republic of Korea ]
• Kyu-Jae Lee [ Department of Environmental Medical Biology, Yonsei University Wonju College of Medicine, Wonju, Gangwon 26427, Republic of Korea, Institute for Poverty Alleviation and International Development, Yonsei University, Wonju Campus, Wonju, Gangwon 26493, Republic of Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국물학회지 [Korean Journal of Waters]

• 간기

  부정기

• pISSN

  2233-4653

• 수록기간

  2010~2021

• 십진분류

  KDC 539 DDC 628