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Hair Growth Promoting Effect of Radish Crude Saponin Extract on Athymic Nude Mice

첫 페이지 보기
  • 발행기관
    국제인공지능학회(구 한국인터넷방송통신학회) 바로가기
  • 간행물
    The International Journal of Advanced Smart Convergence KCI 등재 바로가기
  • 통권
    Volume 8 Number 1 (2019.03)바로가기
  • 페이지
    pp.184-195
  • 저자
    Hyun-Kyoung Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A351898

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원문정보

초록

영어
This study investigates the hair restoration efficacy of selected radish saponin extracts on nude mice. Nude mice genetically predisposed to pattern balding were used in this study. Our study revealed the underlying mechanism of stimulating hair growth in athymic nude mice by repair the nu/nu follicular keratin differentiation defect. Thus, the topical application of radish saponin may represent a novel strategy for the management and therapy of certain forms of alopecia. The term of hair density of PEE treated nude mice were significantly increase as compared with of control nude mice. Histological observation of skin sample showed no hair follicle or only distorted hair follicles were observed in the control samples, in contrast, by the PEE treatment groups showed a fully formed and increased the number of hair follicles up to three times higher than that of control group in terms of the number of hair follicles in nude mouse skin.PEE treated mice the number of BrdU-labeled keratinocytes per anagen follicle increased significantly, especially in the follicular bulbs and outer root sheath compared with the control mice. Moreover, PEE-treated nude mice also exhibited a significant increase in the number of BrdU-labeled epidermal keratinocyte proliferation.

목차

Abstract
1. Introduction
2. Experiment Materials and Methods
2.1 Heat Treatment of Radish and Preparation of Extract
2.2 Extraction and Fractionation of Radish saponin
2.3 Experimental animals
2.4 Administration of PEE and fractions of Radish crude saponin
2.5 Evaluation of hair coverage area
2.6 Evaluation of hair density
2.7 Histologic assessment of hair growth
2.8 Assessment of Keratinocyte Proliferation with Anti-BrdU
2.9 Statistical analysis
3. Result and Discussion
3.1 Macroscopic observation of hair changing pattern on nude mice:
3.2 Evaluation of hair coverage area
3.3 Determination of hair density
3.4 Histological investigation of the skin of nude mouse
3.5 Number of hair follicle
3.6 Stimulates Proliferation of Follicular and Sebaceous Gland Keratinocytes
4. Conclusion
References

키워드

Anagen Radish crude saponin Hair follicle Athymic nude mice BrdU

저자

  • Hyun-Kyoung Kim [ Department of Food Science and Engineering, Seowon University, Cheongju, Korea ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    국제인공지능학회(구 한국인터넷방송통신학회) [The International Association for Artificial Intelligence]
  • 설립연도
    2000
  • 분야
    공학>전자/정보통신공학
  • 소개
    인터넷방송, 인터넷 TV , 방송 통신 네트워크 및 관련 분야에 대한 국내는 물론 국제적인 학술, 기술의 진흥발전에 공헌하고 지식 정보화 사회에 기여하고자 한다.

간행물

  • 간행물명
    The International Journal of Advanced Smart Convergence
  • 간기
    계간
  • pISSN
    2288-2847
  • eISSN
    2288-2855
  • 수록기간
    2012~2025
  • 십진분류
    KDC 326 DDC 380

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