Mi-Ran Kim, Ji-Hae Lee, Hyeon Seok Son, Hayeon Kim
언어
영어(ENG)
URL
https://www.earticle.net/Article/A351876
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Coronaviruses are known respiratory pathogens. In the past, most human coronaviruses were thought to cause mild symptoms such as cold. However recently, as seen in the Severe Acute Respiratory Syndrome (SARS) and the Middle East Respiratory Syndrome (MERS), infectious diseases with severe pulmonary disease and respiratory symptoms are caused by coronaviruses, making research on coronaviruses become important. Considering previous studies, we constructed ‘HCoV-IMDB (Human Corona Virus Immune Database)’ to systematically provide genetic information on human coronavirus and host immune information, which can be used to analyze the interaction between human coronavirus and host immune proteins. The ‘HCoV-IMDB’ constructed in the study can be used to search for genetic information on human coronavirus and host immune protein and to download data. A BLAST search specific to the human coronavirus, one of the database functions, can be used to infer genetic information and evolutionary relationship about the query sequence.
목차
Abstract 1. Introduction 2. Methods 3. Results 3.1 HCoV-IMDB 3.2 BLAST search based on ‘HCoV-IMDB’ 3.3 Phylogenetic analysis using data in ‘HCoV-IMDB’ 4. Discussion 5. Conclusion Acknowledgement References
키워드
DatabaseCoronavirusImmune-proteinBioinformatics
저자
Mi-Ran Kim [ Special Chemistry, Laboratory Medicine, Asan Medical Center, Seoul, Korea ]
Ji-Hae Lee [ Bioinforamtion Technology Division, Bioresources Industrialization Support Department, Nakdonggang National Institute of Biological Resources, Sangju, Gyeongsangbukdo, Korea ]
Hyeon Seok Son [ Laboratory of Computational Biology & Bioinformatics, Institute of Public Health and Environment, Graduate School of Public Health, Seoul National University, Seoul, Korea ]
Hayeon Kim [ Department of Biomedical Laboratory Science, Kyungdong University, Wonju, Gangwondo, Korea ]
Corresponding author