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Anticardiovascular Diseases Effects of Fermented Garlic and Fermented Chitosan
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- 발행기관
- 국제문화기술진흥원 바로가기
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- 간행물
- International Journal of Advanced Culture Technology(IJACT) KCI 등재후보 KCI 등재 바로가기
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- 통권
- Volume 6 Number 4 (2018.12)바로가기
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- 페이지
- pp.109-115
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A348096
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- Garlic is a medicinal plant used throughout the world for its anti-inflammatory, antioxidant, and antiplatelet activities. Chitosan is a natural polysaccharide obtained from chitin, and derivatives of chitosan have been shown to inhibit platelet aggregation and adhesion. We hypothesized that fermented preparations of these products may possess stronger antiplatelet effects than the non-fermented forms owing to the increased bioavailability of the bioactive compounds produced during fermentation. Therefore, we compared these compounds via in vitro and ex vivo platelet aggregation assays by using standard light transmission aggregometry and ex vivo granule secretions from rat platelets. We found that fermented preparations exerted more potent and significant inhibition of platelet aggregation both in vitro and ex vivo. Likewise, ATP release from dense granules of platelets was also significantly inhibited in fermented preparation-treated rat platelets compared to that in non-fermented preparation-treated ones. We concluded that fermented preparations exerted more potent effects on platelet function both in vitro and ex vivo, possibly as a result of the increased bioavailability of active compounds produced during fermentation. We therefore suggest that fermented products may be potent therapeutics against platelet-related CVDs and can be used as antiplatelet and antithrombotic agents.
목차
Abstract
1. Introduction
2. Experiment Materials and Methods
2.1. Reagents
2.2. Sample Preparation
2.3. Experimental animals and dosage
2.4. Preparation of washed platelets
2.5. Garlic and chitosan inhibit in vitro and ex vivo aggregation assay
2.6. Nitric oxide & MTT cell viability assay
2.7. Statistical analysis
3. Result and Discussion
3.1. Garlic and chitosan inhibit in vitro and ex vivo agoniststimulated platelet aggregation
3.2. Garlic and chitosan inhibit ex vivo ATP secretion.
4. Conclusion
Acknowledgments
References
키워드
Cardiovascular diseasess Fermented garlic Fermented chitosan Anti-platelet저자
간행물 정보
발행기관
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- 발행기관명
- 국제문화기술진흥원 [The International Promotion Agency of Culture Technology]
- 설립연도
- 2009
- 분야
- 공학>공학일반
- 소개
- 본 진흥원은 문화기술(Culture Technology) 관련 산·학·연·관으로 구성된 비영리 단체이다. 문화기술(CT)은 정보통신기술(ICT), 문화적 사고 기반의 예술, 인문학, 디자인, 사회과학기술이 접목된 신융합기술(New Convergence Technology, NCT)로 정의한다. 인간의 삶의 질을 향상시키고, 진보된 방향으로 변화시키고, 문화기술 관련 분야의 학술 및 기술의 발전과 진흥에 공헌하기 위하여, 제3조의 필요한 사업을 행함을 그 목적으로 한다.
간행물
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- 간행물명
- International Journal of Advanced Culture Technology(IJACT)
- 간기
- 계간
- pISSN
- 2288-7202
- eISSN
- 2288-7318
- 수록기간
- 2013~2025
- 등재여부
- KCI 등재
- 십진분류
- KDC 600 DDC 700
이 권호 내 다른 논문 / International Journal of Advanced Culture Technology(IJACT) Volume 6 Number 4
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