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Poster Presentation : Reproductive Endocrinology

Melatonin has Synergistic Protective Effect with Ghrelin on Cisplatin-induced Ovarian Damage Via Regulation of FOXO3a Shuttling and p27Kip1 Expression in Primordial Follicl

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Reproductive & Developmental Biology(Supplement) 바로가기
  • 통권
    Volume 41 No 2 Supplement (2017.06)바로가기
  • 페이지
    pp.105-105
  • 저자
    Hoon Jang, Sangho Lee, Sohyeon Moon, Miseon Park, Ok-Hee Lee, Youngsok Choi
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A347590

원문정보

초록

영어
Premature ovarian failure is an important problem for young women with cancer during chemotherapy. To preserve the fertility of young female cancer patients, it is necessary to find out proper methods and materials against chemotherapy-induced ovarian failure. In the previous study, we reported that melatonin treatment partially prevents the depletion of dormant follicle pool via repressing simultaneous activation of dormant primordial follicles by cisplatin. However, the protective effect of melatonin was partial, but not sufficient. Here, we found a hormone, ghrelin to maximize the protective effect of melatonin on ovarian failure in cisplatin-injected mice. Interestingly, co-administration of melatonin and ghrelin more effectively works against follicle disruption by cisplatin. Simultaneous treatment of melatonin and ghrelin almost restored the number of primordial follicles and corpus-luteum in cisplatin-treated ovaries, compared with the single administration group. We found that melatonin and ghrelin receptors were highly present in the cell membrane of premature oocytes of primordial follicles. In addition, both melatonin and ghrelin treatment decreased the phosphorylation of PTEN and FOXO3a resulting in inhibition of FOXO3a’s location in the nucleus and reduction of p27Kip1 expression in primordial follicles. Nuclear FOXO3a and p27Kip1 expression were critical for keeping dormant status of primordial follicles in cisplatin-treated ovary. In conclusion, these findings suggest that combination of melatonin and ghrelin is able to be used in clinics for fertoprotective adjuvant therapy during cisplatin-mediated chemotherapy in young female cancer patients.

키워드

Melatonin Ghrelin Cisplatin Premature ovarian failure FOXO3a P27Kip1

저자

  • Hoon Jang [ Department of Biomedical Science, CHA University, Gyeonggi, Korea ]
  • Sangho Lee [ Department of Biomedical Science, CHA University, Gyeonggi, Korea ]
  • Sohyeon Moon [ Department of Biomedical Science, CHA University, Gyeonggi, Korea ]
  • Miseon Park [ Department of Biomedical Science, CHA University, Gyeonggi, Korea ]
  • Ok-Hee Lee [ Department of Biomedical Science, CHA University, Gyeonggi, Korea ]
  • Youngsok Choi [ Department of Biomedical Science, CHA University, Gyeonggi, Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Reproductive & Developmental Biology(Supplement)
  • 간기
    연간
  • 수록기간
    2001~2017
  • 십진분류
    KDC 527 DDC 636

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