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Poster Presentation : Gene Expression / Function

Distinct Roles of Cep192 and Cep152 in Acentriolar MTOC and Spindle Formation in Mouse Oocytes

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Reproductive & Developmental Biology(Supplement) 바로가기
  • 통권
    Volume 41 No 2 Supplement (2017.06)바로가기
  • 페이지
    pp.55-55
  • 저자
    In-Won Lee, Yu-Jin Jo, Seung-Min Jung, Yong-Han Kim, Nam-Hyung Kim, Suk Namgoong
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A347553

원문정보

초록

영어
Mammalian oocytes lack a centriole that acts as a microtubule organization center (MTOC) in most somatic cells. During oocyte maturation, MTOCs undergo remodeling process including decondensation, fragmentation and self-organization. But the underlined mechanisms of MTOC remodeling in mouse oocyte are not well understood. We showed that two pericentriolar proteins, Cep192 and Cep152 play crucial roles of MTOC remodeling. Cep192 is present in MTOC at all stages of oocyte maturation, and the depletion of Cep192 induces ablation of MTOC, delay inspindle formation and abnormal chromosomal alignment in spindles. In the case of Cep152, Cep152 localization of MTOC is limited at the germinal vesicle (GV) stage and then disappeare from the MTOC after germinal vesicle breakdown (GVBD). Cep152 exclusion from MTOC is involved in the fragmentation of MTOC and it is regulated by CDK1 activity. Together, our results demonstrate the different roles of Cep192 and Cep152 in MTOC remodeling and novel regulatory mechanism during meiotic spindle formation in mouse oocyte.

키워드

Meiosis Cep192 Cep152 MTOC

저자

  • In-Won Lee [ Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea ]
  • Yu-Jin Jo [ Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea ]
  • Seung-Min Jung [ Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea ]
  • Yong-Han Kim [ Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea ]
  • Nam-Hyung Kim [ Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea ]
  • Suk Namgoong [ Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Reproductive & Developmental Biology(Supplement)
  • 간기
    연간
  • 수록기간
    2001~2017
  • 십진분류
    KDC 527 DDC 636

이 권호 내 다른 논문 / Reproductive & Developmental Biology(Supplement) Volume 41 No 2 Supplement

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