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Investigation of the DJ-1 Function in the Higher Mammals

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Reproductive & Developmental Biology(Supplement) 바로가기
  • 통권
    Volume 41 No 2 Supplement (2017.06)바로가기
  • 페이지
    pp.25-25
  • 저자
    Eun Young Kim, Lili Zhuang, Dong Ern Kim, Chi Sun Yun, Eun Ji Lee, Keun Jung Kim, Jae am Lim, Jun Jong Baek, Seung Bum Lim, Min Kyu Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A347532

원문정보

초록

영어
The DJ-1 was found to be the first case that an oncogene also play a role for causative gene of neurodegenerative diseases. The DJ-1 is a multi-functional protein that play important role in tissue and participates in a number of intracellular signaling pathways. Especially, DJ-1 protein has a cellular protective role and promoted cell survival under an oxidative stress. However, the cellular protective mechanism of DJ-1 is not fully understand, and we needs to be further study their functions in canine. In the present study, we investigated the protective role of DJ-1 against induced oxidative stress, cell viability, cell proliferation assay, cellular apoptosis detection analysis, intracellular ROS were measured appropriately. The results showed that DJ-1 overexpressed cells were up-regulated cell viability under oxidative stress conditions, whereas loss of DJ-1 cells were down-regulated the cell survival activity. Additionally, overexpression of DJ-1 cells increased cell resistance to oxidative stress and inhibited the elevation of cell death and cellular ROS induced apoptosis. Moreover, DJ-1 overexpressed cells was increased mitochondrial functions by using confocal microscopy with MitoTracker staining. On the contrary to this, DJ-1 null cells show defective cellular protection and mitochondria activity against oxidative stress conditions. The data indicate that canine DJ-1 protein enhances the cellular survival activity and promote cell survival activity under the oxidative stress by attenuates cellular apoptosis and ROS generation.

키워드

Cell protection Cell survival DJ-1 Oxidative stress

저자

  • Eun Young Kim [ Division of Animal & Dairy Science, Chungnam National University ]
  • Lili Zhuang [ Division of Animal & Dairy Science, Chungnam National University ]
  • Dong Ern Kim [ Division of Animal & Dairy Science, Chungnam National University ]
  • Chi Sun Yun [ Division of Animal & Dairy Science, Chungnam National University ]
  • Eun Ji Lee [ Division of Animal & Dairy Science, Chungnam National University ]
  • Keun Jung Kim [ Chungnam Livestock Research Institute, Cheongyang, Korea ]
  • Jae am Lim [ Chungnam Livestock Research Institute, Cheongyang, Korea ]
  • Jun Jong Baek [ Chungnam Livestock Research Institute, Cheongyang, Korea ]
  • Seung Bum Lim [ Chungnam Livestock Research Institute, Cheongyang, Korea ]
  • Min Kyu Kim [ Division of Animal & Dairy Science, Chungnam National University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Reproductive & Developmental Biology(Supplement)
  • 간기
    연간
  • 수록기간
    2001~2017
  • 십진분류
    KDC 527 DDC 636

이 권호 내 다른 논문 / Reproductive & Developmental Biology(Supplement) Volume 41 No 2 Supplement

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