Jun-Mo Kim, Jong-Eun Park, Inkyu Yoo, Jisoo Han, Namshin Kim, Won-Jun Lim, Eun-Seok Cho, Bonghwan Choi, Sunho Choi, Tae-Hun Kim, Marinus F. W. te Pas, Hakhyun Ka, Kyung-Tai Lee
언어
영어(ENG)
URL
https://www.earticle.net/Article/A347446
원문정보
초록
영어
Female fertility is a highly regulated process involving the synchronized activities of multiple tissues. The underlying genomic regulation of the tissue synchronization is poorly understood. To understand this better we investigated the transcriptomes of the porcine ovary, endometrium, and oviduct at days 0, 3, 6, 9, 12, 15, or 18 of the oestrous cycle. We analysed the transcriptome profiles of the individual tissues and focus on the bridging genes shared by two or more tissues. The three tissue-networks were connected forming a triangular shape. We identified 65 bridging genes with a high level of connectivity to all other genes in the network. The expression levels showed negative correlations between the ovary and the other two tissues, and low correlations between endometrium and oviduct. The main functional annotations involved biosynthesis of steroid hormones, cell-to-cell adhesion, and cell apoptosis, suggesting that regulation of steroid hormone synthesis and tissue viability are major regulatory mechanisms.
Jun-Mo Kim [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Jong-Eun Park [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Inkyu Yoo [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Jisoo Han [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Namshin Kim [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Won-Jun Lim [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Eun-Seok Cho [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Bonghwan Choi [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Sunho Choi [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Tae-Hun Kim [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Marinus F. W. te Pas [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Hakhyun Ka [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
Kyung-Tai Lee [ National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research ]
