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Poster Presentation : Sperm / Male Reproduction

Bioinformatics Annotation of Human X and Y Chromosome-Encoded Proteins associated to Immune Functions

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    발생공학 국제심포지엄 및 학술대회 바로가기
  • 통권
    The 17th International Symposium on Developmental Biotechnology (2017.10)바로가기
  • 페이지
    pp.133-133
  • 저자
    Md Saidur Rahman, Woo-Sung Kwon, Myung-Geol Pang
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A347391

원문정보

초록

영어
Even human genome has been sequenced completely, we have very limited idea of all characterized genes at the protein level. Therefore, several attempts have been taken to map proteome of human chromosome. Since sex chromosomes determined the sex of individual, it important to study sex chromosome-encoded proteins. Here, we studied human sex chromosome- encoded proteins of the immune system, protein pathways, protein-protein interactions, and diseases association using several bioinformatics tools. We retrieved 30 proteins (X chromosome 28; Y chromosome 7; both 5) from the recent NCBI human genome annotation, based on their association with immune systems (immunological and inflammation pathways) by Pathway studio program. Searching of these proteins in the Human Proteome Project, including neXtProt, PeptideAtlas, and the Human Protein Atlas showed that all proteins were also identified in several cells and tissues of body. Proteins were further investigated using Pathway Studio and STRING programs. Pathway Studio and STRING programs showed 15 and 25 X chromosome-encoded proteins were interacted. All Y chromosome-encoded proteins showed interactions using STRING program, however no interaction was found using Pathway studio. In addition, difference in human sex chromosome-encoded proteins of the immune system showed an indirect relationship with the occurrence of some diseases in a sex specific manner.

키워드

Bioinformatics X chromosome Y chromosome Immune system Proteome Diseases

저자

  • Md Saidur Rahman [ Department of Animal Science and Technology, Laboratory of Reproductive Physiology and Modulation, Chung-Ang University, Gyeonggi-Do 17546, Republic of Korea ]
  • Woo-Sung Kwon [ Department of Animal Science and Technology, Laboratory of Reproductive Physiology and Modulation, Chung-Ang University, Gyeonggi-Do 17546, Republic of Korea ]
  • Myung-Geol Pang [ Department of Animal Science and Technology, Laboratory of Reproductive Physiology and Modulation, Chung-Ang University, Gyeonggi-Do 17546, Republic of Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    발생공학 국제심포지엄 및 학술대회 [International Symposium on Developmental Biotechnology]
  • 간기
    연간
  • 수록기간
    2004~2018
  • 십진분류
    KDC 527 DDC 636

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