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Poster Presentation : Sperm / Male Reproduction

The Effects of Peroxiredoxins on Sperm Function and Male Fertility

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    발생공학 국제심포지엄 및 학술대회 바로가기
  • 통권
    The 17th International Symposium on Developmental Biotechnology (2017.10)바로가기
  • 페이지
    pp.131-131
  • 저자
    Do-Yeal Ryu, Woo-Sung Kwon, Md Saidur Rahman, Amena Khatun, Myung-Geol Pang
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A347389

원문정보

초록

영어
Peroxiredoxins (PRDXs), which are essential antioxidant enzymes for physiological activity, have reported that influence sperm function and consequently male fertility. Although PRDXs are well known as important factor to affect male fertility, there has been a lack of attempt to discover the accurate role and mechanism of PRDXs in male fertility. Therefore, the principal objective of this study is to elucidate the role of PRDXs in sperm function and fertilization. We treated mouse spermatozoa with different dose of specific inhibitor of PRDXs, conoidin A (1, 10, or 100 μM). Our results revealed that conoidin A significantly decreased oxidized form of PRDXs (PRDXs-SO3) in mouse spermatozoa. Inhibited PRDXs activity are then resulted in a significant decrease in sperm motility/motion kinematics, viability, mitochondrial membrane potential, and intracellular ATP levels. On the other hand, intracellular levels of ROS and DNA fragmentation index were significantly increased following exposure to conodin A. Next, we evaluated capacitation and acrosome reaction status, and subsequently tyrosine phosphorylation and protein kinase-A activity to investigated underlying mechanism of PRDXs on sperm capacitation status. Capacitation and acrosome reaction were significantly decreased perhaps due to reduction of tyrosine phosphorylation and protein kinase- A activity. Finally, we investigated the effect of PRDXs on fertilization and early embryonic development. Our results described that decreased PRDXs activity significantly decreased fertilization and early embryonic development. Consequently, we demonstrated that inhibition of PRDXs activity has a direct impact on male fertility via decreased important physiological sperm function, eventually resulted in poor fertilisation and embryonic development.

키워드

Peroxiredoxins Male fertility Spermatozoa Sperm function Capacitation

저자

  • Do-Yeal Ryu [ Amena Khatun and Myung-Geol Pang Department of Animal Science and Technology, Laboratory of Reproductive Physiology and Modulation, Chung-Ang University, Gyeonggi-Do 17546, Republic of Korea ]
  • Woo-Sung Kwon [ Amena Khatun and Myung-Geol Pang Department of Animal Science and Technology, Laboratory of Reproductive Physiology and Modulation, Chung-Ang University, Gyeonggi-Do 17546, Republic of Korea ]
  • Md Saidur Rahman [ Amena Khatun and Myung-Geol Pang Department of Animal Science and Technology, Laboratory of Reproductive Physiology and Modulation, Chung-Ang University, Gyeonggi-Do 17546, Republic of Korea ]
  • Amena Khatun [ Amena Khatun and Myung-Geol Pang Department of Animal Science and Technology, Laboratory of Reproductive Physiology and Modulation, Chung-Ang University, Gyeonggi-Do 17546, Republic of Korea ]
  • Myung-Geol Pang [ Amena Khatun and Myung-Geol Pang Department of Animal Science and Technology, Laboratory of Reproductive Physiology and Modulation, Chung-Ang University, Gyeonggi-Do 17546, Republic of Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    발생공학 국제심포지엄 및 학술대회 [International Symposium on Developmental Biotechnology]
  • 간기
    연간
  • 수록기간
    2004~2018
  • 십진분류
    KDC 527 DDC 636

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