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Poster Presentation : Gene Expression / Function

chGRP78 Suppresses Apoptosis by Phosphorylation of AKT1 at Serine 478 in Chicken Cells

첫 페이지 보기
  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    발생공학 국제심포지엄 및 학술대회 바로가기
  • 통권
    The 17th International Symposium on Developmental Biotechnology (2017.10)바로가기
  • 페이지
    pp.41-41
  • 저자
    Hoonsung Choi, Sun Keun Jung, Jeom Sun Kim, Kyung-Woon Kim, Keon Bong Oh, Hyeon Yang, Dong-Hoon Kim, Sung June Byun
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A347322

원문정보

초록

영어
GRP78 is typically expressed in mammalian cells and plays a prominent role in the maintenance of cell homeostasis and development. Additionally, chicken serum-mediated proliferation has regulated the chGRP78 to control prevented apoptosis in chicken cells, thus allowing the required chGRP78-mediated anti-apoptosis. However, the precise molecular mechanisms underlying the chGRP78-mediated apoptosis process remained to be defined. Previously, we reported the effects of chGRP78 on chicken embryo fibroblast (CEF) and DF-1 cell proliferation. Here we identify the AKT1 as a key target of chGRP78 in apoptosis mechanism. Using immunoprecipitation and peptide sequencing, chGRP78 binding sites were detected in AKT1-mediated protein. chGRP78 causes activation of AKT1, and chGRP78 knockdown cells show a decreased level of AKT1. Importantly, activation of AKT1 depletion reciprocally inhibits the apoptosis and promotes proliferation in chicken cells. Taken together, AKT1-mediated signaling pathway plays a critical role in chGRP78-stimulated fibroblast survival and anti-apoptosis, which, suggests an important implications of our findings for the maintenance of chicken fibroblast cells through the inhibition of apoptosis.

키워드

Chicken embryo fibroblast cells AKT1 Cell proliferation Anti-apoptosis

저자

  • Hoonsung Choi [ Animal Biotechnology Division, National Institute of Animal Science, RDA, Wanju-gun 55365, Republic of Korea ]
  • Sun Keun Jung [ Animal Biotechnology Division, National Institute of Animal Science, RDA, Wanju-gun 55365, Republic of Korea ]
  • Jeom Sun Kim [ Animal Biotechnology Division, National Institute of Animal Science, RDA, Wanju-gun 55365, Republic of Korea ]
  • Kyung-Woon Kim [ Animal Biotechnology Division, National Institute of Animal Science, RDA, Wanju-gun 55365, Republic of Korea ]
  • Keon Bong Oh [ Animal Biotechnology Division, National Institute of Animal Science, RDA, Wanju-gun 55365, Republic of Korea ]
  • Hyeon Yang [ Animal Biotechnology Division, National Institute of Animal Science, RDA, Wanju-gun 55365, Republic of Korea ]
  • Dong-Hoon Kim [ Animal Biotechnology Division, National Institute of Animal Science, RDA, Wanju-gun 55365, Republic of Korea ]
  • Sung June Byun [ Animal Biotechnology Division, National Institute of Animal Science, RDA, Wanju-gun 55365, Republic of Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    발생공학 국제심포지엄 및 학술대회 [International Symposium on Developmental Biotechnology]
  • 간기
    연간
  • 수록기간
    2004~2018
  • 십진분류
    KDC 527 DDC 636

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