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The Potential of immunomodulation properties of mesenchymal stem cells in the autoimmune disease (Rheumatoid arthritis)
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- 발행기관
- 한국동물생명공학회(구 한국동물번식학회) 바로가기
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- 간행물
- 발생공학 국제심포지엄 및 학술대회 바로가기
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- 통권
- The 17th International Symposium on Developmental Biotechnology (2017.10)바로가기
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- 페이지
- pp.14-14
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A347305
원문정보
초록
- 영어
- Rheumatoid arthritis (RA) is a common autoimmune disease in the world, and is characterized by synovial hyperplasia, inflammatory cell infiltration, cartilage degradation, bone erosion, joint destruction and an increase in the levels of pro-inflammatory cytokines. Current therapies for RA focus on the inhibition of inflammatory cascade using anti-inflammatory substances to prevent or delay the progression of symptoms, however, the efficacy is varied and limited. Therefore, MSCs are considered as a potential candidate for RA treatment due to their immunomodulation properties in inflammation milieu. Meanwhile, synovial fluid (SF) is a significant source of MSCs in RA therapy; the SF is an easily accessible source of MSCs, which can be obtained during diagnosis or treatment of RA patients without additional harming, in addition, it is well addressed that the population of MSCs derived from SF (SF-MSCs) in arthritis patients is extensively increased in comparison to that in healthy patients. Hence, we have investigated whether the immunomodulation properties of SF-MSCs are capable of improving the symptoms of RA as the new therapeutic approach. For the purpose of the aforementioned objective, we have conducted: establishment of the method for isolation of SF and bone marrow (BM) specimens from minipigs, exploration of the most stable reference genes in porcine MSCs for the further analysis, comparative evaluations between porcine SF- and BM-MSCs with respect to the pluripotent capacities and the immunomodulation properties in RA animal model, comparative characterizations of human SF-MSCs obtained from different disease-graded RA patients, identification for alterations of immunomodulation properties depending on the degree of inflammation milieu in SF-MSCs from human RA patients, and establishment of new large animal RA model in minipig. We hope that these results can contribute to better understand the pathogenesis and etiology of RA as well as develop new therapeutic strategy.
저자
간행물 정보
발행기관
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- 발행기관명
- 한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
- 설립연도
- 1976
- 분야
- 농수해양>축산학
- 소개
- 동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.
간행물
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- 간행물명
- 발생공학 국제심포지엄 및 학술대회 [International Symposium on Developmental Biotechnology]
- 간기
- 연간
- 수록기간
- 2004~2018
- 십진분류
- KDC 527 DDC 636
이 권호 내 다른 논문 / 발생공학 국제심포지엄 및 학술대회 The 17th International Symposium on Developmental Biotechnology
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