Geunho Choi, Sejeong Yoon, Kye- II Joo, Sungjune Jung, Hyung Joon Cha
언어
한국어(KOR)
URL
https://www.earticle.net/Article/A346319
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원문정보
초록
영어
Alginate has been widely used in hydrogel- based tissue engineering area as an excellent carbohydrate biomaterial due to its good biocompatibility and easy gelation by cation induction such as calcium ions. 3D bioprinting has been regarded as a powerful tool for mimicking natural structure, because it can fabricate on-demanded hierarchical artificial tissues. Due to several advantages of alginate, it has been the most frequently used biomaterial in inkjet-based bioprinting area. However, this ionically crosslinked alginate IS noticeably impoverished under a physiological, aqueous conditions due to easy loss of calcium ions. Thus, the low structural integrity and poor mechanical stability limited long-term cell culture on alginate-based bioprinted structures. While barium or copper IOns can increase its stability, these also increase cytotoxic effects. In this work, we proposed a new visible light- activated crosslinkable alginate-based bioink, showing fast and non -cytotoxic gelation. We constructed 3D cell-laden structures using this novel alginate material and various cell types. The light/ionic double crosslinked alginate bioink showed excellent biocompatibility, increased mechanical properties, and improved dimensional stability. Further development of this novel alginate- based 3D inkjet bioink may facilitate preparation of transplantable human tissues.
저자
Geunho Choi [ Department of Chemical Engineering, POSTECH, Pohang 37673, Korea ]
Sejeong Yoon [ School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang 37673, Korea ]
Kye- II Joo [ Department of Chemical Engineering, POSTECH, Pohang 37673, Korea ]
Sungjune Jung [ School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang 37673, Korea ]
Hyung Joon Cha [ Department of Chemical Engineering, POSTECH, Pohang 37673, Korea ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.