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DC-SIGN expressiOn m Hofbauer cells may play an important role in immune tolerance in fetal chorionic villi during the development of preeclampsia.

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2018 한국당과학회 연례학술대회 (2018.07)바로가기
  • 페이지
    pp.42-43
  • 저자
    SW Yang, YK Kim, MK Kim, M Park, MJ Kim, HS Hwang, YS Kang
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A346315

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원문정보

초록

영어
Immune tolerance at feto-maternal interfaces is a complex phenomenon. Although maternal decidual macrophages are well-known immune cells, little is known about fetal-derived macrophages (Hofbauer cells) within chorionic villi. Preeclampsia (PE) is a major cause of maternal mortality in the field of obstetrics, and the innate immunological role of maternal decidual macrophages is well known. In this study, we assessed the differential phenotypes and marker expressiOn m fetal macrophages, known as dendritic cell- specific ICAM -grabbing nonintegrin (DC-SIGN) -positive Hofbauer cells. We compared Hofbauer cell properties between normal and PE placenta chorionic villi and performed sequential staining of DC-SIGN, CD14, and CD68 to evaluate the existence of Hofbauer cells. Furthermore, to evaluate the immunological function of these cells, we stained the cells for CD163, a marker of immunoregulatory type 2 (M2) macrophages. Additionally, we examined the expression of the immunosuppressive cytokine interleukin (IL) -10, which is known to be produced by M2 macrophages. DCSIGN +/CD14+, DC-SIGN +/CD68+, and CD163+/DC-SIGN + cells were quantified based on photomicrographs. The results showed that CD14, CD163, DC-SIGN, and IL-10 levels were significantly downregulated in PE compared with normal. Additionally, CD 163 +/DC -SIGN+ Hofbauer cells were significantly less frequent in PE than in normal. DC-SIGN Hofbauer cells produced IL-10 at lower levels in the PE than in the normal. Thus, we speculate that fetal-derived Hofbauer cells may play an important role in normal pregnancy with immunosuppressive effects based on their M2 macrophage characteristics to maintain immune tolerance during pregnancy. Additionally, in PE, these functions were defective, supporting the roles of these macrophages in PE development.

저자

  • SW Yang [ Department of Obstetn'cs and gynecology, Konkuk University, Medicine Department Pharmacology and Toxicology, Konkuk University, Veterinary Medicine ]
  • YK Kim [ Department of Obstetn'cs and gynecology, Konkuk University, Medicine Department Pharmacology and Toxicology, Konkuk University, Veterinary Medicine ]
  • MK Kim [ Department of Obstetn'cs and gynecology, Konkuk University, Medicine Department Pharmacology and Toxicology, Konkuk University, Veterinary Medicine ]
  • M Park [ Department of Obstetn'cs and gynecology, Konkuk University, Medicine Department Pharmacology and Toxicology, Konkuk University, Veterinary Medicine ]
  • MJ Kim [ Department of Obstetn'cs and gynecology, Konkuk University, Medicine Department Pharmacology and Toxicology, Konkuk University, Veterinary Medicine ]
  • HS Hwang [ Department of Obstetn'cs and gynecology, Konkuk University, Medicine Department Pharmacology and Toxicology, Konkuk University, Veterinary Medicine ]
  • YS Kang [ Department of Obstetn'cs and gynecology, Konkuk University, Medicine Department Pharmacology and Toxicology, Konkuk University, Veterinary Medicine ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

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