Paracrine effects of human U937 macrophages on mini pig adipose tissue-derived mesenchymal stem cell differentiation: the possibility of NM23-H1 as a ganglioside GD3 suppressor
Sung Youn Heo, You Na Seo, Won Seok Ju, Hyun Gyu Lim, Sang-Young Seo, Jin Hyoung Cho, Park Soon Ju, Young-Kug Choo
언어
영어(ENG)
URL
https://www.earticle.net/Article/A346291
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원문정보
초록
영어
Mesenchymal stem cells are undifferentiated stem cells that can differentiate into various cells and tissues. In this study, we confirmed the difference in expression and differentiation rate of gangliosides during the differentiation of mini-pig adipose-derived mesenchymal stem cells into neuronal cells using secretion medium from PMA-induced human macrophage-like cell line U937 (Macro SM). We showed that nm23, one of several proteins secreted in the culture medium of activated human macrophages, decreased the neuronal differentiation rate of mesenchymal stem cells derived from mini-pig adipose, and inhibited the function and the synthesis enzyme of GD3. In conclusion, one of the factors that decreased the differentiation rate of mini-pig adipose-derived mesenchymal stem cells into neuronal cells by Macro SM is the nm23 protein.
저자
Sung Youn Heo [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea ]
You Na Seo [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea ]
Won Seok Ju [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea ]
Hyun Gyu Lim [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea ]
Sang-Young Seo [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea ]
Jin Hyoung Cho [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea Institute for glycoscience, Wonkwang University, Iksan, Jeonbuk 54538, Korea ]
Park Soon Ju [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea ]
Young-Kug Choo [ Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea Institute for glycoscience, Wonkwang University, Iksan, Jeonbuk 54538, Korea ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.