O-GlcNAcylation is a carbohydrate post-translational sugar modification occurs on hydroxyl groups of serine or threonine residues of cytosolic and nuclear proteins. It is known that O-GlcNAc addition and removal regulate many biological events like transcription, protein degradation, proliferation. Epithelial-mesenchymal transition(EMT) is a process that epithelial cells lose its polarity and cell-cell contact, therefore get migratory capabilities to become mesenchymal stem cells. There are several reports that O-GlcNAc is associated with cancer EMT and metastasis. But there are still much to discover the role of O-GlcNAc on TGF-β-induced EMT. TGF-β is one of the powerful EMT inducer, and is primarily dependent on TGF-β/Smad signaling pathway. Here we found that Smad protein expression is regulated by global O-GlcNAc change, consequentially controls TGF-β-induced EMT. Now we’re planning to verify how O-GlcNAc controls Smad expression.
저자
Yeon Jung Kim [ Department of Systems Biology, 2Department of integrated OMICS for Biomedical Science, GNRC(Glycosylation Network Research Cecter), Yonsei University ]
Eunah Kim [ Department of Systems Biology, 2Department of integrated OMICS for Biomedical Science, GNRC(Glycosylation Network Research Cecter), Yonsei University ]
Jin Won Cho [ Department of Systems Biology, 2Department of integrated OMICS for Biomedical Science, GNRC(Glycosylation Network Research Cecter), Yonsei University ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.