Ki-Hoon Song, Mi So Park, Tulip S. Nandu, Shrikanth Gadad, Sang-Cheol Kim, Mi-Young Kim
언어
영어(ENG)
URL
https://www.earticle.net/Article/A346254
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원문정보
초록
영어
Polypeptide N-acetyl-galactosaminyltransferases (GALNTs) have been shown to play diverse roles in several biological processes, but their function in organ-tropic metastasis remains unknown. Here, we find that GALNT14expression is specifically associated with pulmonary metastasis in breast cancer patients. Furthermore, we demonstrate that GALNT14 promotes lung metastasis by facilitating two important steps during the metastatic process, i.e., initiation of metastatic colonies and their subsequent growth into overt metastases. Mechanistic studies suggest that GALNT14 not only augments self-renewal of breast cancer cells within the lung microenvironment but also allows breast cancer cells to exploit macrophage-derived growth factors for their continuous growth. The mediators of GALNT14 involved in these processes will also be discussed.
저자
Ki-Hoon Song [ Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea ]
Mi So Park [ Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea ]
Tulip S. Nandu [ Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea ]
Shrikanth Gadad [ Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea ]
Sang-Cheol Kim [ Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea ]
Mi-Young Kim [ Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.