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Treadmill exercise and wheel exercise improve motor function by suppressing apoptotic neuronal cell death in brain inflammation rats

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초록

영어
Brain inflammation is involved in many brain disorders, such as brain ischemic injury, Alzheimer diseases, and Parkinson disease. Physical exercise has been recommended for the prevention and treatment of many brain inflammatory diseases. In the present study, the effects of exercise on motor function in relation with apoptotic neuronal cell death following neuroinflammation were investigated. Moreover, we compared the effect of forced exercise with voluntary exercise on neu-roinflammation-induced motor malfunction. For this study, rota-rod test, vertical pole test, foot fault test, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, immunohistochemis-try for caspase-3, and western blot for Bcl-2 and Bax were performed. Lipopolysaccharide was intraventricular infused for induction of brain inflammation. Treadmill exercise and wheel exercise were conducted during 6 weeks. In the present results, Treadmill exercise and wheel ex-ercise alleviated brain inflammation-induced motor impairments by suppressing apoptotic neuronal cell death in the motor cortex. These effects of treadmill exercise and wheel exercise were similarly ap-peared.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals and grouping
Induction of brain inflammation
Treadmill exercise protocol
Wheel exercise protocol
Rota-rod test
Vertical pole test
Foot fault test
Tissue preparation
Western blot analysis
TUNEL assay
Caspase-3 immunohistochemistry
Data analysis
RESULTS
Rota-rod test
Vertical pole test
Foot fault test
Bcl-2 and Bax expressions in the motor cortex
TUNEL-positive cells in the motor cortex
Caspase-3 expression in the motor cortex
DISCUSSION
CONFLICT OF INTEREST
REFERENCES

저자

  • Sang-Hyuk Song [ Department of Physical Activity Design, Hanseo University, Seosan, Korea ]
  • Yong-Seok Jee [ Department of Physical Activity Design, Hanseo University, Seosan, Korea ]
  • Il-Gyu Ko [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
  • Sang-Won Lee [ Department of Physical Education, Korea Military Academy, Seoul, Korea ]
  • Young-Je Sim [ Department of Physical Education, Kunsan National University, Gunsan, Korea ]
  • Dae-Young Kim [ Department of Sports Healthcare, College of Humanities & Social Sciences, Inje University, Gimhae, Korea ]
  • Sam-Jun Lee [ Department of Physical Education, College of Health, Welfare, and Education, Tong Myong University, Busan, Korea ]
  • Young Sam Cho [ Department of Urology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국운동재활학회 [Korean Society of Exercise Rehabilitation]
  • 설립연도
    2004
  • 분야
    의약학>재활의학
  • 소개
    한국운동재활학회는 사회적, 정신적, 신체적 통합건강복지 이론의 학술연구와 회원 상호간 학술교류 증진을 장려함으로써 학문적 발전을 도모하고 나아가 건강복지선진국 발전에 이바지함을 목적으로 한다.

간행물

  • 간행물명
    JER [Journal of Exercise Rehabilitation]
  • 간기
    격월간
  • ISSN
    2288-176X
  • E-ISSN
    2288-1778
  • 수록기간
    2013~2019
  • 등재여부
    KCI 등재,SCOPUS
  • 십진분류
    KDC 514.03 DDC 617.03

이 권호 내 다른 논문 / JER Vol.14 No.6

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