Earticle

초록

영어

Nicotine is a major component of tobacco and the addictive substance in cigarette smoke. Wide use of e-cigarette has been leading acute intoxication of nicotine in recent days in Korea. In this study, acute nicotine and antihistamines intoxications in two suicidal cases are reported. A male and a female were found dead in a hotel. Near the victims, two disposable syringes filled with about 5 mL of brown liquid and two empty e-cigarette liquid bottles labeled with ‘HO-OOO’ pure nicotine solution were found. Several injection marks were found on the back of left hands in each person. A series of forensic autopsy specimens were collected and analyzed. Nicotine, doxylamine(DA) and Diphenhydramine(DPH) were detected in two victim’s biologic specimens. Liquid chromatography/Tandem mass spectrometry(LC/MS/MS) was used for identification and quantification of the detected drugs. Femoral venous blood, heart blood, bile, urine, cerebrospinal fluid, gastric contents and tissue at the injection site were collected and analyzed for drug testing. The concentrations of nicotine in femoral blood in male and female victim were 4.85 mg/L and 0.60 mg/L, respectively. The concentrations of DA were 1.48 mg/L and 0.84 mg/L, and the concentrations of DPH were 1.06 mg/L and 0.16 mg/L in femoral blood in male and female victim, respectively. Based on these results, we determined the cause of death in these suicidal cases could be multidrug poisoning involving nicotine, DA and DPH.

목차

Abstract
I. Introduction
II. Introduction
2.1 Chemicals and reagents
2.2 Case history
2.3 Sample preparation
2.4 LC/MS/MS analysis
III. Results and discussion
IV. References

키워드

저자

• 박미정 [ Meejung Park | 국립과학수사연구원 법독성학과 ] Corresponding author
• 심주현 [ Juhyun Sim | 국립과학수사연구원 법독성학과 ]
• 인상환 [ Sangwhan In | 국립과학수사연구원 법독성학과 ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국법과학회지 [Korean Journal of Forensic Science]

• 간기

  반년간

• pISSN

  1598-0715

• 수록기간

  2000~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 367 DDC 347