Earticle

초록

영어

Stress is the physiological responses of organisms to harmful or threat-ening stimuli that allow appropriate behavioral responses to the stress-or. In the present study, the effect of treadmill exercise on stress-in-duced anxiety was evaluated using rats. To induce stress, the rats were exposed to an inescapable electric foot shock. Exposure of rats to the electric foot shock was performed for 7 days. The rats in the exercise groups were made to run on a motorized treadmill for 30 min once a day for 4 weeks stating one day after last electric food shock. Anxiety-like behaviors were determined by open field test and elevated plus-maze test. The expressions of c-Fos and neuronal nitric oxide synthase (nNOS) in the hypothalamus and locus coeruleus were detected by im-munohistochemistry. In the present results, locomotor activity in the center of the open field test and the number of entries and time in the open arms of the elevated plus-maze test were reduced in the rats with stress-induced anxiety. Treadmill running enhanced these locomotor activities, the number of entries and time in the stress-induced anxiety rats. c-Fos and nNOS expressions in the hypothalamus and locus coe-ruleus were increased in the stress-induced rats. Treadmill exercise re-duced c-Fos and nNOS overexpressions in the stress-induced rats. In the present study, treadmill exercise ameliorated anxiety-like behaviors in the stress-induced rats. The improving effect of treadmill exercise on anxiety-like behaviors might be ascribed to the suppressing effect of exercise on c-Fos and nNOS expressions.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Experimental animals and treatments
  Induction of stress
  Exercise protocol
  Open field test
  Elevated plus-maze test
  Tissue preparation
  Immunohistochemistry for c-Fos and nNOS
  Statistical analysis
 RESULTS
  Anxiety-like behaviors
  Expressions of c-Fos and nNOS in the hypothalamus
  Expressions of c-Fos and nNOS in the locus coeruleus
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Jin-Hee Seo [ Department of Adaptive Physical Education, Baekseok University, Cheonan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613