Earticle

초록

영어

Epilepsy is characterized by recurrent seizures and loss of neurons with abnormal rhythmic firing in the brains. In the present study, we investi-gated the effect of treadmill exercise on memory function in relation with cell proliferation and apoptosis in the hippocampus using pilocar-pine-induced seizure rats. Epilepsy was initiated by intraperitoneal in-jection of pilocarpine hydrochloride. The rats in the exercise group were forced to run on a motorized treadmill for 30 min once a day for 2 weeks. In the present results, treadmill exercise alleviated short-term and spatial learning memory impairments in the epileptic rats. Treadmill exercise suppressed neuronal degeneration and enhanced neuronal maturation in the epileptic rats. Treadmill exercise suppressed cell pro-liferation and apoptosis in the epileptic rats. Treadmill exercise alleviat-ed pilocarpine-induced memory impairments and suppressed neuronal loss in the hippocampus through down-regulation of apoptosis. These findings offer a possibility that treadmill exercise may provide a preven-tive or therapeutic value to the epilepsy-induced learning and memory impairments.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Experimental animals
  Pilocarpine-induced epilepsy
  Treadmill exercise protocol
  Step-down avoidance task
  Radial-arm maze task
  Tissue preparation
  BrdU Immunohistochemistry
  Immunohistochemistry for NeuN, caspase-3, DCX
  TUNEL staining
  Fluoro-Jade B staining
  Western blot analysis
  Statistical analysis
 RESULTS
  Latency of the step-down avoidance task
  Correct number and error number of the radial-arm maze task
  Fluoro-Jade B-positive and NeuN-positive cells in the hippocampal CA1 region
  BrdU-positive and DCX-positive cells in the hippocampal dentate gyrus
  Caspase-3-positive and TUNEL-positive cells in the hippocampal CA1 region
  Bax and Bcl-2 expressions in the hippocampus
 DISCUSSION
 CONFLICT OF INTEREST
 REFERENCES

키워드

저자

• Jae-Min Lee [ Department of Pharmacology, School of Medicine, The Catholic University of Korea, Seoul, Korea ]
• Eun-Sang Ji [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Mal-Soon Shin [ School of Global Sport Studies, Korea University, Sejong, Korea ]
• Baek-Vin Lim [ Division of Leisure & Sports Science, Department of Exercise Prescription, Dongseo University, Busan, Korea ]
• Yong-Rak Chung [ Department of Golf Mapping, College of Arts Physical Education, Joongbu University, Geumsan, Korea ]
• Young Sam Cho [ Department of Urology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613