Earticle

초록

영어

Sarcopenia is an age-associated decline of skeletal muscle mass and function and is known to lead to frailty, cachexia, osteoporosis, meta-bolic syndromes, and death. Notwithstanding the increasing incidence of sarcopenia, the molecular and cellular mechanisms driving age-re-lated sarcopenia are not completely understood. This article reviews current definitions of sarcopenia, its potential mechanisms, and effects of exercise on sarcopenia. The pathogenesis of age-related sarcopenia is multifactorial and includes myostatin, inflammatory cytokines, and mitochondria-derived problems. Especially, age-induced mitochondrial dysfunction triggers the production of reactive oxygen species (ROS) by mitochondria, impedes mitochondrial dynamics, interrupts mitophagy, and leads to mitochondria-mediated apoptosis. Aerobic exercise pro-vides at least a partial solution to sarcopenia as it ameliorates mito-chondria-derived problems, and resistance exercise strengthens mus-cle mass and function. Furthermore, combinations of these exercise types provide the benefits of both. Collectively, this review summarizes potential mechanisms of age-related sarcopenia and emphasizes the use of exercise as a therapeutic strategy, suggesting that combined ex-ercise provide

목차

Abstract
 INTRODUCTION
 POTENTIAL MECHANISMS OFAGE-RELATED SARCOPENIA
  Mitochondrial reactive oxygen species & mitochondrial dysfunction
  Mitochondrial apoptosis
  Mitochondrial dynamics
  Mitochondrial autophagy
  Myostatin
  Inflammatory cytokines
 EFFECTS OF EXERCISE ON SARCOPENIA
  Aerobic exercise and sarcopenia
  Resistance exercise and sarcopenia
  Combined exercise and sarcopenia
 CONCLUSIONS
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Su-Zi Yoo [ Department of Kinesiology, Inha University, Incheon, Korea ]
• Mi-Hyun No [ Department of Kinesiology, Inha University, Incheon, Korea ]
• Jun-Won Heo [ Department of Kinesiology, Inha University, Incheon, Korea ]
• Dong-Ho Park [ Department of Kinesiology, Inha University, Incheon, Korea ]
• Ju-Hee Kang [ Department of Pharmacology and Medicinal Toxicology Research Center, Inha University School of Medicine, Incheon, Korea ]
• So Hun Kim [ Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea ]
• Hyo-Bum Kwak [ Department of Kinesiology, Inha University, Incheon, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613