Earticle

초록

영어

Depression is a major cause of disability and one of the most common public health problems. In the present study, antidepressive effect of treadmill exercise on chronic mild stress (CMS)-induced depression in rats was investigated. For this, sucrose intake test, immunohistochem-istry for 5-bromo-2’-deoxyuridine, terminal deoxynucleotidyl transfer-ase-mediated dUTP nick end-labeling staining, and Western blot analy-sis for brain-derived neurotrophic factor, cyclic adenosine monophos-phate response element binding protein, and endothelial nitric oxide synthase were conducted. Following adaptation to the animal vivarium and two baseline fluid intake tests, the animals were divided into four groups: the control group, the CMS-induced depression group, the CMS-induced depression and exercise group, and the CMS-induced depression and fluoxetine-treated group. The animals in the CMS groups were exposed to the CMS conditions for 8 weeks and those in the control group were exposed to the control conditions for 8 weeks. After 4 weeks of CMS, the rats in the CMS-induced depression and ex-ercise group were made to run on a motorized treadmill for 30 min once a day for 4 weeks. In the present results, treadmill exercise alleviated CMS-induced depressive symptoms. Treadmill exercise restored su-crose consumption, increased cell proliferation, and decreased apop-totic cell death. The present results suggest the possibility that exercise may improve symptoms of depression.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Sucrose intake test
  Chronic mild stress
  Treadmill exercise protocol
  Fluoxetine treatment
  Tissue preparation
  BrdU immunohistochemistry
  TUNEL staining
  Western blot
  Data analysis
 RESULTS
  Sucrose intake test
  Numbers of BrdU-positive cells
  Numbers of TUNEL-positive cells
  BDNF expression
  CREB expression
  eNOS expression
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Taeck-Hyun Lee [ Department of Family Medicine, Dae Dong Hospital, Busan, Korea ]
• Kijeong Kim [ School of Exercise & Sport Science, College of Natural Sciences, University of Ulsan, Ulsan, Korea ]
• Mal-Soon Shin [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Baek-Vin Lim [ Division of Leisure & Sports Science, Department of Exercise Prescription, Dongseo University, Busan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613