Earticle

초록

영어

Maternal infection is an important factor causing neonatal brain injury and later developmental disability. In the present study, we investigated the effects of treadmill exercise intensity on short-term memory, hippo-campal neurogenesis, and expression of brain-derived neurotrophic factor (BDNF), and tyrosine kinase receptor B (TrkB) in the rats born of lipopolysaccharide (LPS)-exposed maternal rats. The rats were divided into six groups: control group, mild-intensity exercise group, moder-ate-intensity exercise group, maternal LPS-exposed group, maternal LPS-exposed and mild-intensity exercise group, maternal LPS-exposed and moderate-intensity exercise group. The rats in the exercise groups were forced to run on a treadmill for 30 min 5 times a week for 4 weeks. The exercise load consisted of running at the speed of 8 m/min for the mild-intensity exercise groups and 14 m/min for moderate-intensity ex-ercise groups. The latency in the step-down avoidance task was deter-mined for the short-term memory. Immunohistochemistry for 5-bro-mo-2’-deoxyuridine was performed to determine hippocampal cell pro-liferation and neurogenesis. Western blot analysis was performed for the detection of BDNF and TrkB expression. In the present study, tread-mill exercise improved short-term memory deteriorated by maternal LPS exposure. Treadmill exercise increased cell proliferation and neu-rogenesis in the hippocampal dentate gyrus of the rats born of the LPS-exposed maternal rats. Treadmill exercise increased BDNF and TrkB expression in the hippocampus of the rats born of the LPS-ex-posed maternal rats. These effects of treadmill exercise were similarly appeared at both mild-intensity and moderate-intensity.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Exercise protocol
  Step-down avoidance task
  Tissue preparation
  BrdU immunohistochemistry
  Western blot analysis
  Data analysis
 RESULTS
  Effect of treadmill exercise on the short-term memory
  Effect of treadmill exercise on the cell proliferation and cell survival in the hippocampal dentate gyrus
  Effect of treadmill exercise on the expressions of BDNF and TrkB in the hippocampus
 DISCUSSION
 CONFLIC OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Kijeong Kim [ School of Exercise & Sport Science, College of Natural Sciences, University of Ulsan, Ulsan, Korea ]
• Yun-Hee Sung [ Department of Physical Therapy, College of Natural Science, Kyungnam University, Changwon, Korea ]
• Jin-Hee Seo [ Division of Sports Science, Baekseok University, Cheonan, Korea ]
• Sang-Won Lee [ Department of Physical Education, Korea Military Academy, Seoul, Korea ]
• Baek-Vin Lim [ Division of Leisure & Sports Science, Department of Exercise Prescription, Dongseo University, Busan, Korea ]
• Choong-Yeol Lee [ Department of Oriental Physiology, Gachon University College of Oriental Medicine, Seongnam, Korea ]
• Yong-Rak Chung [ Department of Golf Mapping, College of Arts Physical Education, Joongbu University, Geumsan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613