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SYNERGISTIC EFFECTS OF COCONUT OIL WITH ATORVASTATIN ON THE CHOLESTEROL LEVELS OF GUINEA PIGS

첫 페이지 보기
  • 발행기관
    국제과학영재학회 바로가기
  • 간행물
    APEC Youth Scientist Journal 바로가기
  • 통권
    Vol. 4 (2012.08)바로가기
  • 페이지
    pp.153-159
  • 저자
    Maxine Helga Pinpin, Gian Paolo B. Sepulveda, Marian Camille C. Obrero, Ms. Rose Butaran
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A328911

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초록

영어
Most cardiovascular diseases (CVD) are caused by high levels of cholesterol and lipoproteins, specifically Low Density Lipoproteins (LDL), in the blood, heart and liver. In response to the growing number of patients with heart-related diseases, this study was conducted to determine the synergistic effects of coconut oil with the leading cholesterollowering medicine, atorvastatin on the lipid profile of guinea pigs (Cavia percellus), particularly the Total Cholesterol to high-density lipoprotein (TC: HDL) ratio, which is considered one of the best markers in determining CVD risk. After blood samples were taken for initial lipid analysis, the guinea pigs were subjected to four treatments: coconut oil, statins, statins with coconut, oil and a control group. After two weeks of administering the treatments, blood was extracted again for the new lipoprotein levels. Data was analyzed using two-way ANOVA (α = 0.05). Results show that decrease in the TC:HDL ratio induced by coconut oil was lower than the decrease induced by atorvastatin. Interestingly, the group with coconut oil and statins, yielded the greatest decrease in the TC: HCL ratio. This shows the positive synergy of coconut oil and statins in decreasing CVD risk. The information provided in this study will aid in the improvement of current medicine.

목차

ABSTRACT
 1. INTRODUCTION
 2. RESEARCH METHODS
  2.1. Procurement of Guinea Pigs, Coconut Oil and Statins
  2.2. Determination of Initial Lipoprotein Levels
  2.3. Feeding of Coconut Oil and Statins
  2.4. Determination of Final Lipoprotein levels
 3. RESULTS AND DISCUSSION
  3.1. Tables of Results
  3.2. Discussion
 4. CONCLUSION
 5. RECOMMENDATIONS
 6. ACKNOWLEDGEMENTS
 7. REFERENCES

키워드

coconut oil total cholesterol to high-density lipoprotein (TC:HDL) ratio lowdensity lipoproteins (LDL) atorvastatin cardiovascular disease (CVD) risk

저자

  • Maxine Helga Pinpin [ Philippine Science High School – Main Campus, Agham Road, Quezon City, Metro Manila 1004, Philippines ] Corresponding author
  • Gian Paolo B. Sepulveda [ Philippine Science High School – Main Campus, Agham Road, Quezon City, Metro Manila 1004, Philippines ]
  • Marian Camille C. Obrero [ Philippine Science High School – Main Campus, Agham Road, Quezon City, Metro Manila 1004, Philippines ]
  • Ms. Rose Butaran [ Philippine Science High School – Main Campus, Agham Road, Quezon City, Metro Manila 1004, Philippines ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    국제과학영재학회 [The Society for the International Gifted in Science]
  • 설립연도
    2006
  • 분야
    자연과학>자연과학일반
  • 소개
    과학영재를 위한 연구 활동을 통하여 과학영재를 발굴하고, 발굴된 과학영재가 과학 분야의 관련 연구 활동을 할 수 있도록 지원하여, 이들이 과학 관련 분야의 진로를 선택하도록 장려함으로써 국제경쟁력을 갖춘 우수 과학기술인을 배출하고 국가 경제발전 및 문화창달과 세계 과학 발전에 기여함을 목적으로 한다.

간행물

  • 간행물명
    APEC Youth Scientist Journal [APEC 청소년 과학학술지]
  • 간기
    반년간
  • pISSN
    2005-5625
  • 수록기간
    2009~2022
  • 십진분류
    KDC 405 DDC 505

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