Earticle

초록

영어

The apolipoprotein E (APOE) gene has been suggested to be associated with stroke and dementia. However, the effects of exercise training on dementia according to the APOE genotype are not consistent to those reported by previous studies. Therefore, we examined the effects of ex-ercise training on stroke risk factors including blood pressure, lipid pro-files, homocysteine (Hcy) concentrations, and cognitive function ac-cording to the APOE genotype in stroke patients. We examined the stroke risk factors, Hcy, and cognitive function in 28 ischemic stroke pa-tients before and after 6 months of exercise training. After exercise training, body weight, body mass index (BMI), and percent body fat de-creased significantly in both APOE groups. According to the APOE gen-otype, the changes in BMI in the APOE ε4 group higher than those in APOE ε3 group significantly. Total cholesterol (TC), low-density lipopro-tein (LDL)-C, triglyceride (TG), and Hcy decreased and high-density lipo-protein (HDL)-C increased significantly in the both groups. According to the APOE genotype, systolic blood pressure in the APOE ε4 group de-creased, but in the APOE ε3 group increased after exercise training. TC, LDL-C, and TG in the APOE ε4 group decreased more extensively than those in the APOE ε3 group after exercise training. VO2max (maximal oxy-gen consumption) and cognition increased significantly in both groups. Folate acid intake also increased significantly in both groups. The APOE genotype affects variations in the risk factors of stroke after exercise training. However, the Hcy and cognitive function did not differ based on the APOE genotype.

목차

Abstract
 INTRODUCTION
 METERIALS AND METHODS
  Subjects
  Anthropometry measurements
  Cognition measurements
  Ascertainment of diet intake
  Blood collection and assessment of biomarkers
  Genotyping
  Preliminary testing
  Exercise training
  Statistical analysis
 RESULTS
  The changes in body composition after exercise training according to APOE genotype
  The changes in stroke risk factors after exercise training according to the APOE genotype
  The changes in cardiorespiratory fitness and cognition after exercise training according to the APOE genotype
  The changes in vitamin 6 and folate acid intake during exercise training according to the APOE genotype
 DISCUSSION
 CONFLICT OF INTEREST
 REFERENCES

키워드

저자

• Jun-Hee Lee [ Department of Physical Education, Centre for Sport Medicine, Kyung Hee University, Seoul, Korea ]
• Sang-Min Hong [ Department of Physical Education, College of Education, Dongguk University, Seoul, Korea ]
• Yun-A Shin [ Department of Prescription & Rehabilitation of Exercise, College of Physical Exercise, and Department of Kinesiologic Medical Science, Graduate School Dankook University, Cheonan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613