Earticle

초록

영어

Background: Vitamin D has been associated with sepsis in pediatric and adult patients. The association with neonates is unclear. This systematic review and meta-analysis examined the effect of neonatal and maternal vitamin D levels on neonatal early-onset sepsis. Methods: We searched studies published up to November 2017 in PubMed/Medline, Embase, and the Cochrane Library databases. All studies that reported 25-hydroxyvitamin D levels in neonates with or without early-onset sepsis were included. Meta-analysis was performed using RevMan 5.3 software. Results: Four studies were eligible. The weighted mean difference of 25-hydroxyvitamin D levels in neonates with early-onset sepsis and controls was -7.27 ng/mL (95% confidence interval = -7.62, - 6.92). Maternal vitamin D levels in neonates with early-onset sepsis were significantly lower than those in controls (weighted mean difference -7.24 ng/mL, 95% confidence interval -8.45, -6.03). All neonates with early onset sepsis had vitamin D deficiency (25- hydroxyvitamin D <20 ng/mL). Conclusion: Lower neonatal and maternal 25-hydroxyvitamin D levels were associated with neonatal early-onset sepsis. Vitamin D supplementation during pregnancy may be helpful to prevent neonatal early-onset sepsis. The effects of vitamin D supplementation on early-onset sepsis in neonates warrant further study.

목차

ABSTRACT
 연구 방법
  문헌 검색
  문헌 선택
  자료 추출
  질 평가(Quality assessment)
  자료의 통합 및 분석
 연구 결과
  문헌 검색 결과
  대상 연구의 특성 및 질 평가 결과
  신생아 조기 패혈증과 신생아 혈중 비타민 D 농도와의 관계
  신생아 조기 패혈증에 대한 산모의 혈중 비타민 D 농도와 비타민 D 공급의 영향
 고찰 및 결론
 감사의 말씀
 참고문헌

키워드

저자

• 이소연 [ So Yeon Lee | 원광대학교 약학대학 ]
• 김하은 [ Ha Eun Kim | 원광대학교 약학대학 ]
• 안숙희 [ Sook Hee An | 원광대학교 약학대학 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615