Earticle

초록

영어

The role of plasma glutamine concentration and glutamine supplemen-tation on immunosuppression was investigated in combat athletes. Twenty-three male athletes were randomly assigned to receive gluta-mine (21 g/day, n=12) or placebo (ovalbumin, n=11) for 10 days. Six athletes who did not lose weight served as controls. Athletes were as-sessed 21 days before (-21d), 1 day before (-1d) and 5 days after (+5d) a competition. Weight reduction was similar between glutamine (-8.2%± 4.1%) and placebo (-8.5%±2.4%) and negligible in control (-0.6%±1.4%). In both weight-loss groups, the majority of athletes reported symptoms of upper respiratory symptoms, as assessed by the Wisconsin upper respiratory symptom survey questionnaire. Only two athletes reported symptoms in the control group. Immune cell function remained un-changed throughout the study except for an increase in neutrophil phagocytic activity (placebo: -21d=5,251±2,986; -1d=17,428±22,374; +5d=21,125±21,934; glutamine: -21d=6,096±3,549; -1d=11,029±17,113; +5d=28,186±21,032 FI) and a minor change in monocyte phagocytic activity (placebo: -21d=4,421±3,634; -1d=3,329±6,283; +5d=3,243± 2,553; glutamine: -21d=4,051±3,186; -1d=3,106±2,625; +5d=4,981± 4,598) in both glutamine and placebo after weight loss. Plasma gluta-mine and cortisol remained unchanged across the study. creatine ki-nase levels were increased in placebo (-21d=125.2±54.1; -1d=187.2± 73.5; +5d=111.3±59.1 U/L) but not in glutamine (-21d=136.2±58.2; -1d= 168.8±65.0; +5d=129.7±64.0 U/L). Rapid weight loss increased the fre-quency and severity of infection symptoms, but this was neither associ-ated with plasma glutamine depletion nor counteracted by glutamine supplementation.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Participants
  Study design
  Supplementation protocol
  Blood sampling
  Serum and plasma analysis
  Body composition
  Dietary assessment
  Upper respiratory infection symptoms
  Neutrophil and monocyte phagocytic activity and oxidative burst
  Statistical analysis
 RESULTS
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 SUPPLEMENTARY MATERIAL
 REFERENCES

키워드

저자

• Aline C. C. Tritto [ Applied Physiology in Nutrition & Exercise Research Group, University of Sao Paulo, Sao Paulo, Brazil ]
• Mariane T. Amano [ Laboratory of Transplantation Immunobiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil ]
• Maria E. De Cillo [ Applied Physiology in Nutrition & Exercise Research Group, University of Sao Paulo, Sao Paulo, Brazil ]
• Vinicius A. Oliveira [ Laboratory of Transplantation Immunobiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil ]
• Sandro H. Mendes [ Applied Physiology in Nutrition & Exercise Research Group, University of Sao Paulo, Sao Paulo, Brazil ]
• Caroline Yoshioka [ Applied Physiology in Nutrition & Exercise Research Group, University of Sao Paulo, Sao Paulo, Brazil ]
• Hamilton Roschel [ Applied Physiology in Nutrition & Exercise Research Group, University of Sao Paulo, Sao Paulo, Brazil ]
• Niels Olsen S. Camara [ Laboratory of Transplantation Immunobiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil ]
• Bruno Gualano [ Applied Physiology in Nutrition & Exercise Research Group, University of Sao Paulo, Sao Paulo, Brazil ]
• Guilherme G. Artioli [ Applied Physiology in Nutrition & Exercise Research Group, University of Sao Paulo, Sao Paulo, Brazil ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613