Earticle

초록

영어

Previously, we monitored the expression level of the pro-apoptotic proteins caspase-3 and cleaved poly-ADP-ribose polymerase in the skeletal muscle of high-fat diet-induced obese rats in order to assess muscle damage. In this study, we analyzed whether exercise or dietary adjustment was more effective at preventing high-fat diet-induced muscle damage. High-fat diet-induced obese rats were divided into three groups: the high-fat diet (HFD), the combined high-fat diet and exercise (HFD+EXE), and the dietary adjustment (DA) groups. For 6 weeks, the HFD+EXE group was subjected to exercise on an animal treadmill. Capsase-3 protein was quantified, and histopathology of the soleus muscle was performed. Both the HFD+EXE and DA interventions resulted in a reduction of lipid accumulation in the soleus muscle, and nucleus infiltration was significantly lower in the DA group. The inflammatory response, caspase-3 level, and relative muscle weight were significantly higher in the HFD+EXE group compared to the HFD group. An increase in intramyocellular lipids in the soleus muscle by obesity and exercise stimulated apoptosis. When the rats exercised, muscle growth was normal and unrelated to the effects of lipid accumulation. These data indicate that exercise was more effective than dietary adjustment in reducing lipid accumulation and increasing muscle metabolism.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals
  Exercise protocol
  Measurements
  Casapase-3 Western blot
  Statistical analysis
 RESULTS
  Body weight gain, food intake, and food efficiency ratio
  Abdominal adipose tissue weight and relative muscle weight
  IMCL accumulation in the soleus muscle
  Macrophage infiltration and cell regeneration
  Caspase-3 expression (activation level of apoptosis)
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Kyung-Wan Baek [ Division of Sport Science, Pusan National University, Busan, Korea, Department of Parasitology and Genetics, Kosin University College of Medicine, Busan, Korea ]
• Hee-Jae Cha [ Department of Parasitology and Genetics, Kosin University College of Medicine, Busan, Korea ]
• Mee Sun Ock [ Department of Parasitology and Genetics, Kosin University College of Medicine, Busan, Korea ]
• Hong Soo Kim [ Department of Gastroenterology/Hepatology, Soonchunhyang University College of Medicine, Cheonan, Korea ]
• Jeong-An Gim [ Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, Korea ]
• Jung-Jun Park [ Division of Sport Science, Pusan National University, Busan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613