Earticle

초록

영어

Social isolation is known to precipitate depression-like symptoms in ro-dents and has emerged as a dependable paradigm to screen the be-havioral and neurobiological changes observed in humans. In the pres-ent study, the undying mechanisms of treadmill exercise on social isola-tion-induced depression was evaluated. The rat pups in the social iso-lation groups were housed individually. The social isolation procedures started on the postnatal day 14. The rat pups in the exercise groups were forced to run on treadmill for 30 min once a day from postnatal day 21 to postnatal day 34. The expression of phosphoinositide 3 kinase (PI3K), tyrosine kinase B (Akt), and glycogen synthase kinase 3β (GSK-3β) in the hippocampus were determined by using western blot analy-sis. The ratio phosphorylated PI3K (p-PI3K)/PI3K and phosphorylated Akt (p-Akt)/Akt were decreased and the ratio of phosphorylated-GSK-3 (p-GSK-3β)/GSK-3β was increased by social isolation. Treadmill exer-cise increased the ratio p-PI3K/PI3K and p-Akt/Akt and suppressed the ratio of p-GSK-3β/GSK-3β in the hippocampus of social isolated rat pups. Treadmill exercise activates PI3K/Akt signaling pathway leading to GSK-3β inhibition in social isolated rats. These results suggested that tread-mill exercise may improve depressive symptoms via activation of PI3K/Akt signaling pathway.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Tissue preparation
  Western blot analysis
  Data analysis
 RESULTS
  PI3K and p-PI3K expression in the hippocampus
  Akt and p-Akt expression in the hippocampus
  GSK-3β and p- GSK-3β expression in the hippocampus
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Lin Ru Wang [ Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea ]
• Seung-Soo Baek [ Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613